Evidence map›Paper›PMID 35578217›Full record

ArticleBMC public health2022

Adverse childhood experiences and comorbidity in a cohort of people who have injected drugs.

David W Sosnowski, Kenneth A Feder, Jacquie Astemborski, Becky L Genberg, Elizabeth J Letourneau, Rashelle J Musci, Ramin Mojtabai, Lisa McCall, Eileen Hollander, Lynnet Loving and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Coping strategy as a predictor of illicit drug use among persons who inject drugs.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

David W Sosnowski *Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Kenneth A Feder *Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Jacquie AstemborskiDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Becky L GenbergDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Elizabeth J LetourneauDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Rashelle J MusciDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Ramin MojtabaiDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Lisa McCallDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Eileen HollanderDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Lynnet LovingDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Brion S MaherDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Gregory D KirkDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Shruti H MehtaDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Jing SunDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. jsun54@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
Pharmacogenomics of ART adherence and effectiveness in the ALIVE CohortR01DA047064 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D, MAHER, BRION S · 2018 to 2023
$5.8M
Elimination of HCV and related liver disease among HIV-infected and -uninfected people who inject drugsR01DA048063 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta, David L Thomas · 2019 to 2026
$4.2M
Collaboration on HIV and AgingResearch through the Study of MitochondriaK01AI162247 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Jing Sun · 2022 to 2026
$677k
Collateral Consequences of the United States Opioid Epidemic for ChildrenF31DA044699 · NIDA · JOHNS HOPKINS UNIVERSITY · PI FEDER, KENNETH · 2017 to 2018
$82k
NIAID NIH HHS K01 AI162247NIDA NIH HHS F31 DA044699NIDA NIH HHS R01 DA047064NIDA NIH HHS R01 DA048063NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

backgroundChildhood adversity is associated with the onset of harmful adult substance use and related health problems, but most research on adversity has been conducted in general population samples. This study describes the prevalence of adverse childhood experiences in a cohort of people who have injected drugs and examines the association of these adverse experiences with medical comorbidities in adulthood.

methodsSix hundred fifty three adults were recruited from a 30-year cohort study on the health of people who have injected drugs living in and around Baltimore, Maryland (Median age = 47.5, Interquartile Range = 42.3-52.3 years; 67.3% male, 81.1% Black). Adverse childhood experiences were assessed retrospectively in 2018 via self-report interview. Lifetime medical comorbidities were ascertained via self-report of a provider diagnosis. Multinomial logistic regression with generalized estimating equations was used to examine the association between adversity and comorbid conditions, controlling for potential confounders.

resultsTwo hundred twelve participants (32.9%) reported 0-1 adverse childhood experiences, 215 (33.3%) reported 2-4, 145 (22.5%) reported 5-9, and 72 (11.1%) reported ≥10. Neighborhood violence was the most commonly reported adversity (48.5%). Individuals with ≥10 adverse childhood experiences had higher odds for reporting ≥3 comorbidities (Adjusted Odds Ratio = 2.9, 95% CI = 1.2 - 6.8, p = .01).

conclusionsAmong people who have injected drugs, adverse childhood experiences were common and associated with increased occurrence of self-reported medical comorbidities. Findings highlight the persistent importance of adversity for physical health even in a population where all members have used drugs and there is a high burden of comorbidity.

Indexed as

Adverse Childhood ExperiencesSubstance-Related DisordersAdultCohort StudiesComorbidityFemaleHumansMaleMiddle AgedPrevalenceRetrospective StudiesAdverse childhood experiencesComorbiditySubstance use

Identifiers

PMID35578217
PMCPMC9109307
OpenAlexW4280523021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.