Evidence map›Paper›PMID 35582906›Full record

ArticlemSphere2022

Acacia Fiber Protects the Gut from Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Colonization Enabled by Antibiotics.

Marlène Maeusli, Nicholas Skandalis, Bosul Lee, Peggy Lu, Sarah Miller, Jun Yan, Yuli Talyansky, Rachel Li, Zeferino Reyna, Noel Guerrero and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Marlène MaeusliDepartment of Medicine, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.ORCID 0000-0003-0953-9646
Nicholas SkandalisDepartment of Medicine, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.ORCID 0000-0002-4236-8909
Bosul LeeDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Peggy LuDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Sarah MillerDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Jun YanDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Yuli TalyanskyDepartment of Medicine, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Rachel LiDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Zeferino ReynaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Noel GuerreroDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Amber UlhaqDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Matthew SlarveDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.
Ioannis TheologidisDepartment of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Brad Spellberg *Los Angeles County + University of Southern Californiagrid.42505.36 Medical Center, Los Angeles, California, USA.
Brian Luna *Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.ORCID 0000-0001-6718-4551
University of Southern California · USNational and Kapodistrian University of Athens · GR

Funding

MAb Passive Vaccination against Acinetobacter baumanniiR01AI130060 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRAD J SPELLBERG · 2017 to 2026
$6.7M
Humanized Monoclonal Antibody to Treat Acinetobacter InfectionsR42AI106375 · NIAID · BIOLOGICAL ANTI-INFECTIVE MEDICINES, LLC · PI ISLAM, KHALID · 2016 to 2018
$3.1M
Transferrin Combination Therapy to Address Antimicrobial ResistanceR01AI117211 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2016 to 2019
$2.7M
Characterization of Rifabutin Therapy Against Antibiotic-Resistant BacteriaR01AI139052 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUNA, BRIAN MICHAEL · 2018 to 2021
$2.4M
Multivalent Adjuvant Immunization to Prevent Hospital Acquired InfectionsR41AI145759 · NIAID · EXBAQ LLC · PI SPELLBERG, BRAD J · 2020 to 2021
$594k
Transferrin As a Novel Approach to Combat MucormycosisR21AI132923 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2018 to 2019
$454k
NIAID NIH HHS R01 AI117211NIAID NIH HHS R01 AI130060NIAID NIH HHS R01 AI139052NIAID NIH HHS R21 AI132923NIAID NIH HHS R41 AI145759NIAID NIH HHS R42 AI106375
6 · The paper itself

Abstract

Novel approaches to combating antibiotic resistance are needed given the ever-continuing rise of antibiotic resistance and the scarce discovery of new antibiotics. Little is known about the colonization dynamics and the role of intrinsic plant-food characteristics in this process. We sought to determine whether plant fiber could alter colonization dynamics by antibiotic-resistant bacteria in the gut. We determined that ingestion of antibiotics in mice markedly enhanced gut colonization by a pathogenic extended-spectrum beta-lactamase-producing Escherichia coli strain of human origin, E. coli JJ1886 (ST131-

Indexed as

AcaciaEscherichia coliAnimalsAnti-Bacterial Agentsbeta-LactamasesMammalsMiceRNA, Ribosomal, 16SAnti-Bacterial Agentsbeta-LactamasesRNA, Ribosomal, 16Santibiotic resistancecolicinESBLEscherichia colifibergut microbiomehost-pathogen interactionsinfectious diseaseOne Health

Identifiers

PMID35582906
PMCPMC9241499
OpenAlexW4280526959

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.