Evidence map›Paper›PMID 35585250›Full record

SynthesisJournal of exposure science & environmental epidemiology2023

Associations of cadmium exposure with risk of metabolic syndrome and its individual components: a meta-analysis.

Liping Lu, Yuexia Li, Cheng Chen, Yijia Zhang, Wenzhi Guo, Shuijun Zhang, Ka Kahe

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of exposure science & environmental epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liping Lu *Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Yuexia Li *Department of Intensive Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Cheng ChenDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Yijia ZhangDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Wenzhi GuoKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Shuijun ZhangKey Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Ka KaheDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA. kk3399@columbia.edu.

Funding

Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
Trace mineral levels, metabolomics, and diabetes riskR01DK116603 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2018 to 2019
$1.5M
NIA NIH HHS RF1 AG056111NIDDK NIH HHS R01 DK116603
6 · The paper itself

Abstract

Data directly associating cadmium (Cd) with metabolic syndrome (MetS) are sparse and inconsistent. We aimed to quantitatively assess the association of Cd exposure with risk of MetS and its individual components. Literature searching was performed in PubMed, EMBASE, and MEDLINE-OVID through September, 2021. Weighted odds ratios (ORs) for MetS and its components were pooled by comparing the highest to the lowest category of Cd exposure using random-effects models. Eleven (10 from Asia and 1 from the US) cross-sectional studies (33,887 participants and 7176 cases) were identified. Overall, Cd exposure was not associated with risk of MetS [OR: 1.08, 95% confidence interval (CI): 0.92, 1.28]. However, the association became significant when pooling Asian studies (OR: 1.18, 95% CI: 1.02, 1.35), and it was more pronounced with Cd measured in blood (OR: 1.24, 95% CI: 1.05, 1.45). Additionally, Cd exposure was significantly associated with reduced HDL-cholesterol (OR: 1.27, 95% CI: 1.05, 1.54) and elevated triglyceride (OR: 1.17, 95% CI: 1.05, 1.30), but not other components. This meta-analysis indicates that Cd exposure is associated with risk of MetS among Asian populations, which is mainly explained by Cd's association with dyslipidemia. Further studies are needed to better understand the mechanism of action.

Indexed as

Metabolic SyndromeCadmiumCross-Sectional StudiesHumansOdds RatioRisk FactorsCadmiumAsianBiomarkerCadmiumLipid metabolismMeta-analysisMetabolic syndrome

Identifiers

PMID35585250

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.