ArticleBMC cardiovascular disorders2022
Prevalence and risk factors for vascular calcification based on the ankle-brachial index in the general population: a cross-sectional study.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- The Linear Association Between A Body Shape Index and Abdominal Aortic Calcification in Individuals With Hypertension.Clinical cardiology · 2026Article
- Association Between Calcium Supplementation and Recurrence of Cardiovascular Events in Patients With Cardiovascular Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Cell Calcification Models and Their Implications for Medicine and Biomaterial Research.Advanced healthcare materials · 2026Review
- Association of serum uric acid with incident vascular calcification in patients with type 2 diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Functional outcomes and rehabilitation behaviors following ankle sprain in amateur padel players: a cross-sectional study.Frontiers in medicine · 2026Article
- Vascular Calcification Patterns in the Elderly: Correlation Between Aortic and Iliac Calcification Burden.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Association of prognostic nutritional index and severe abdominal aortic calcification in middle-aged adults: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome.Endocrine connections · 2025Article
- Article
- A high burden of diabetes and ankle brachial index abnormalities exists in Mexican Americans in South Texas.Preventive medicine reports · 2024Article
- Evaluation of laboratory values affecting mortality of end-stage renal disease patients: a competing risks approach.BMC nephrology · 2023Article
- Ectopic Calcification: What Do We Know and What Is the Way Forward?Journal of clinical medicine · 2023Article
- Salt-Sensitive Hypertension: Mediation by Salt-Induced Hypervolemia and Phosphate-Induced Vascular Calcification.Clinical Medicine Insights. Cardiology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the prevalence of vascular calcification based on the ankle-brachial index (ABI) value and analyse the risk factors for vascular calcification in the general population.
methodsA cross-sectional study was conducted to collect clinical, laboratory, and lifestyle data in individuals aged 30-70 recruited from the physical examination centre. The automatic arteriosclerosis detector was used to measure the ABI. Difference tests, correlation analyses, and multivariate logistic regression analyses were performed to identify risk factors for vascular calcification.
resultsThe overall prevalence of vascular calcification was 24.39% in 1033 subjects. The prevalence of vascular calcification in males was much higher than that in females (27.80% vs. 17.49%, P < 0.001). The differences in age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), hypertension, and fatty liver disease were statistically significant in males (P < 0.05). The differences between serum uric acid (UA), total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), alcohol consumption, exercise, and postmenopausal status were statistically significant in females (P < 0.05). Increased age (odds ratio (OR) = 1.028, 95% confidence interval (CI) 1.008-1.049, P = 0.007), increased BMI (OR = 1.238, 95% CI 1.147-1.337, P < 0.001) and elevated DBP (OR = 2.563, 95% CI 1.262-5.205, P = 0.009) were independent risk factors for vascular calcification in males after adjusting for confounding factors. Increased BMI (OR = 1.159, 95% CI 1.029-1.304, P = 0.015), elevated UA (OR = 1.545, 95% CI 1.077-2.216, P = 0.018), elevated LDL-C (OR = 1.044, 95% CI 1.060-1.027, P < 0.001), and a lack of exercise (OR = 2.402, 95% CI 1.073-5.373, P = 0.033) were independent risk factors for vascular calcification in females.
conclusionsThe prevalence of vascular calcification based on the ABI value is also high in the general population of our centre. Increased age, BMI, and elevated DBP are independent risk factors for vascular calcification in males. Increased BMI, UA, LDL-C, and a lack of exercise are independent risk factors for vascular calcification in females. Attention should be given to strengthening the prevention and control of vascular calcification in the general population.
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