Evidence map›Paper›PMID 35589130›Full record

ArticleGenes & development2022

RBM33 directs the nuclear export of transcripts containing GC-rich elements.

Anu Thomas, Frederick Rehfeld, He Zhang, Tsung-Cheng Chang, Mohammad Goodarzi, Frank Gillet, Joshua T Mendell

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Article
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  6. Article
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  8. Gene regulation through exon junction complex modularity.Nature structural & molecular biology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. RBM33 is a unique mMolecular cell · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anu ThomasDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Frederick RehfeldDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
He ZhangQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Tsung-Cheng ChangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Mohammad GoodarziDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Frank GilletDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Joshua T MendellDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID 0000-0001-8479-2284
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · US

Funding

Targeting Mutant KRAS for Cancer TherapyR35CA197731 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SEBTI, SAID M · 2016 to 2022
$6.2M
The intersection of RNA biology and tumor biologyR35CA197311 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MENDELL, JOSHUA T · 2015 to 2021
$5.1M
Howard Hughes Medical InstituteNCI NIH HHS R35 CA197311NCI NIH HHS R35 CA197731
6 · The paper itself

Abstract

Although splicing is a major driver of RNA nuclear export, many intronless RNAs are efficiently exported to the cytoplasm through poorly characterized mechanisms. For example, GC-rich sequences promote nuclear export in a splicing-independent manner, but how GC content is recognized and coupled to nuclear export is unknown. Here, we developed a genome-wide screening strategy to investigate the mechanism of export of

Indexed as

Nucleocytoplasmic Transport ProteinsRNA, ViralActive Transport, Cell NucleusCell NucleusRNA TransportNucleocytoplasmic Transport ProteinsRNA, ViralGC contentGC-rich elementslncRNAslong noncoding RNAsNORADnuclear exportRBM33

Identifiers

PMID35589130
PMCPMC9186391
OpenAlexW4280588546

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.