Evidence map›Paper›PMID 35592653›Full record

ArticleFrontiers in cellular and infection microbiology2022

Cryptic Genes for Interbacterial Antagonism Distinguish

Victoria I Verhoeve, Tyesha D Fauntleroy, Riley G Risteen, Timothy P Driscoll, Joseph J Gillespie

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Rickettsioses Seropositivity in Malaysia: A Six-Year Trend, 2016-2021.Tropical medicine and infectious disease · 2025
    Article
  2. Article
  3. Review
  4. Identification ofInsects · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023
    Article
  11. Coinfection of TwoMicrobiology spectrum · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Victoria I VerhoeveDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Tyesha D FauntleroyDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Riley G RisteenDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
Timothy P DriscollDepartment of Biology, West Virginia University, Morgantown, WV, United States.
Joseph J GillespieDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · USWest Virginia University · US

Funding

Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged TickR21AI156762 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DRISCOLL, TIMOTHY P, GILLESPIE, JOSEPH J · 2021 to 2022
$435k
Rickettsia cell envelope glycoconjugates are derived from the host cell amino sugar biosynthesis pathwayR21AI146773 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J, RAHMAN, MOHAMMED SAYEEDUR · 2019 to 2020
$425k
Investigating Rickettsia Interspecies and Host-Specific Lipopolysaccharide VariationR21AI166832 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J · 2022 to 2023
$425k
NIAID NIH HHS R21 AI146773NIAID NIH HHS R21 AI156762
6 · The paper itself

Abstract

Background: The genus Methods: To improve estimates for assessing Results: REIS_1424 has few analogs in other Rickettsiales genomes and greatest similarity to non-Proteobacteria proteins. This cohort of proteins varies greatly in size and domain composition, possessing characteristics of Recombination hotspot (Rhs) and contact dependent growth inhibition (CDI) toxins, with similarity limited to proximal C-termini (~145 aa). This domain was named CDI-like/Rhs-like C-terminal toxin (CRCT). As such proteins are often found as toxin-antidote (TA) modules, we interrogated REIS_1423 (151 aa) as a putative antidote. Indeed, REIS_1423 is similar to proteins encoded upstream of CRCT domain-containing proteins. Accordingly, we named these proteins CDI-like/Rhs-like C-terminal toxin antidotes (CRCA). Conclusion: We hypothesize that

Indexed as

IxodesRickettsiaAnimalsAntidotesHumansMammalsPhylogenySymbiosisAntidotesblacklegged tickcontact-dependent growth inhibition systemsIxodes scapularislateral gene transferLyme diseaserecombination hot spotRickettsia buchneritoxin-antidote

Identifiers

PMID35592653
PMCPMC9111745
OpenAlexW4225391128

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.