ArticleeLife2022
Visceral organ morphogenesis via calcium-patterned muscle constrictions.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Article
- Lights up on the embryonic dance: tools and applications of optogenetics in developmental biology.Genes & development · 2026Review
- DynamicAtlas: a morphodynamic atlas for Drosophila development.Nature methods · 2026Article
- Topology and kinetic pathways of colloidosome assembly and disassembly.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Blender tissue cartography: an intuitive tool for the analysis of dynamic 3D microscopy data.bioRxiv : the preprint server for biology · 2025Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- Stochastic morphological swings inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanics of Drosophila wing deployment.Nature communications · 2024Article
- Hox gene activity directs physical forces to differentially shape chick small and large intestinal epithelia.Developmental cell · 2024Article
- Active shape programming drivesScience advances · 2024Article
- The sex of organ geometry.Nature · 2024Article
- Spiking at the edge: Excitability at interfaces in reaction-diffusion systems.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- TubULAR: tracking in toto deformations of dynamic tissues via constrained maps.Nature methods · 2023Article
- From cells to form: A roadmap to study shape emergence in vivo.Biophysical journal · 2023Review
- Spatio-temporal patterning of extensile active stresses in microtubule-based active fluids.PNAS nexus · 2023Article
- Patterning of morphogenetic anisotropy fields.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Morphogenetic Roles of Hydrostatic Pressure in Animal Development.Annual review of cell and developmental biology · 2022Review
- Controlling the shape and topology of two-component colloidal membranes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A squash and a squeeze.eLife · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Organ architecture is often composed of multiple laminar tissues arranged in concentric layers. During morphogenesis, the initial geometry of visceral organs undergoes a sequence of folding, adopting a complex shape that is vital for function. Genetic signals are known to impact form, yet the dynamic and mechanical interplay of tissue layers giving rise to organs' complex shapes remains elusive. Here, we trace the dynamics and mechanical interactions of a developing visceral organ across tissue layers, from subcellular to organ scale in vivo. Combining deep tissue light-sheet microscopy for in toto live visualization with a novel computational framework for multilayer analysis of evolving complex shapes, we find a dynamic mechanism for organ folding using the embryonic midgut of
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.