Evidence map›Paper›PMID 35598697›Full record

ArticleExperimental gerontology2022

Valsartan and sacubitril combination treatment enhances collagen production in older adult human skin cells.

Sela Marin, Inês Godet, Lolita S Nidadavolu, Jing Tian, Laura E Dickinson, Jeremy D Walston, Daniele M Gilkes, Peter M Abadir

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental gerontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Potential use of angiotensin receptor blockers in skin pathologies.Iranian journal of basic medical sciences · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sela MarinDivision of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Inês GodetDepartment of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21228, USA; Department of Oncology, Johns Hopkins University School of Medicine, 1650 Orleans Street, MD 21287, USA.
Lolita S NidadavoluDivision of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Jing TianDivision of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Laura E DickinsonJoVE Producer and Publisher of Video Resources, USA.
Jeremy D WalstonDivision of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Daniele M GilkesDepartment of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21228, USA; Department of Oncology, Johns Hopkins University School of Medicine, 1650 Orleans Street, MD 21287, USA. Electronic address: dgilkes1@jhu.edu.
Peter M AbadirDivision of Geriatrics and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. Electronic address: pabadir1@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Translational Aging Research Training ProgramT32AG058527 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir, Esther Seunghee Oh · 2018 to 2026
$4.0M
Age Related Change in Mitochondrial Angiotensin System and Mitochondrial DeclineR01AG046441 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M. · 2014 to 2018
$2.3M
Novel Formulation of Topical Losartan for Treatment of Wounds in AgingR21AG043284 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M., WALSTON, JEREMY D · 2013 to 2014
$446k
NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG046441NIA NIH HHS R21 AG043284NIA NIH HHS T32 AG058527
6 · The paper itself

Abstract

Collagen is a major component of the skin's support system, allowing for its firmness, elasticity, and mechanical strength. Skin collagen production decreases as we age and is associated with increased sagging, wrinkling, and thinning. The Renin-Angiotensin System (RAS) is a key hormonal system that changes with age and affects multiple organ systems. The primary health benefits of Angiotensin (Ang) receptor type1 (AT

Indexed as

Angiotensin Receptor AntagonistsHeart FailureAgedAminobutyratesAngiotensin-Converting Enzyme InhibitorsBiphenyl CompoundsCollagenDrug CombinationsHumansNeprilysinStroke VolumeTetrazolesTreatment OutcomeValsartanAminobutyratesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBiphenyl CompoundsCollagenDrug CombinationsNeprilysinsacubitrilTetrazolesValsartanAgingAngiotensinCollagenSkinValsartan

Identifiers

PMID35598697
PMCPMC10793626
OpenAlexW4280497378

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.