ArticleJournal of Alzheimer's disease : JAD2022
Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA).
Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Effects of Hearing Intervention on Physical Activity Measured by Accelerometry: A Secondary Analysis of the ACHIEVE Study.Journal of the American Geriatrics Society · 2025Trial
- A sensorimotor function construct to assess mild cognitive impairment risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Not just how much, but how it's done: movement activity bout distributions and everyday cognition in older adults with elevated dementia risk.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Accelerometry-derived activity fragmentation as a predictor of brain atrophy and disability progression in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Sustained physical activity offers benefits beyond activity volume in chronic disease prevention.Nature communications · 2026Article
- Every move counts: but some more than others.The international journal of behavioral nutrition and physical activity · 2026Article
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
- Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.Medicine and science in sports and exercise · 2025Article
- Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop.Frontiers in public health · 2025Article
- Purpose in life and accelerometer-measured physical activity among older adults.Psychology & health · 2025Article
- Differences in Daily Physical Activity by Alzheimer's Risk Markers Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Cross-sectional associations between patterns and composition of upright and stepping events with physical function: insights from The Maastricht Study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Wearable Technologies for Healthy Ageing: Prospects, Challenges, and Ethical Considerations.The Journal of frailty & aging · 2024Article
- Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment.Advanced biology · 2023Review
- Activity variability: A novel physical activity metric and its association with cognitive impairment.Alzheimer's & dementia (New York, N. Y.)Article
- Beyond aggregate volume-Accelerometer-derived activity phenotypes reveal a decoupling of lean mass and function: A cross-sectional study.Science progressArticle
- Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (New York, N. Y.)Article
- Article
- Directionality between cognitive function and daily physical activity patterns.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundGradual disengagement from daily physical activity (PA) could signal present or emerging mild cognitive impairment (MCI) or Alzheimer's disease (AD).
objectiveThis study examined whether accelerometry-derived patterns of everyday movement differ by cognitive diagnosis in participants of the Baltimore Longitudinal Study of Aging (BLSA).
methodsActivity patterns, overall and by time-of-day, were cross-sectionally compared between participants with adjudicated normal cognition (n = 549) and MCI/AD diagnoses (n = 36; 5 participants [14%] living with AD) using covariate-adjusted regression models.
resultsCompared to those with normal cognition, those with MCI/AD had 2.1% higher activity fragmentation (SE = 1.0%, p = 0.036) but similar mean total activity counts/day (p = 0.075) and minutes/day spent active (p = 0.174). Time-of-day analyses show MCI/AD participants had lower activity counts and minutes spent active during waking hours (6:00 am-5:59 pm; p < 0.01 for all). Also, they had lower activity fragmentation from 12:00-5:59 am (p < 0.001), but higher fragmentation from 12:00-5:59 pm (p = 0.026).
conclusionDifferences in the timing and patterns of physical activity throughout the day linked to MCI/AD diagnoses warrant further investigation into potential clinical utility.
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