Evidence map›Paper›PMID 35601068›Full record

ArticleExperimental and therapeutic medicine2022

Inonotsuoxide B suppresses hepatic stellate cell activation and proliferation via the PI3K/AKT and ERK1/2 pathway.

Juan Jin, Hui Yang, Lili Hu, Yinghong Wang, Wenyong Wu, Chengmu Hu, Kun Wu, Zehua Wu, Wenming Cheng, Yan Huang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Molecular medicine reports · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Juan JinInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Hui YangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Lili HuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Yinghong WangDepartment of Pharmacy, Division of Life Sciences and Medicine, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China.
Wenyong WuDepartment of General Surgery, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230041, P.R. China.
Chengmu HuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Kun WuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Zehua WuInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Wenming ChengInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Yan HuangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230032, P.R. China.
Anhui Provincial Hospital · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic stellate cells (HSCs) serve a pivotal role in the formation and degradation of the extracellular matrix during liver fibrosis. Inonotsuoxide B is a tetracyclic triterpenoid that can be extracted from

Indexed as

hepatic stellate cellsinonotsuoxide BInonotus obliquusliver fibrosisplatelet-derived growth factor

Identifiers

PMID35601068
PMCPMC9117953
OpenAlexW4282918963

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.