Evidence map›Paper›PMID 35603182›Full record

ReviewFrontiers in immunology2022

Fatty Acid Metabolism and T Cells in Multiple Sclerosis.

Saige L Pompura, David A Hafler, Margarita Dominguez-Villar

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Complex Interplay Between Metabolism and CD4Cardiovascular drugs and therapy · 2024
    Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saige L PompuraDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, United States.
David A HaflerDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, United States.
Margarita Dominguez-VillarFaculty of Medicine, Imperial College London, London, United Kingdom.

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI VIJAY K. KUCHROO · 1996 to 2026
$51.7M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4M
Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9M
Transgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI HAFLER, DAVID A. · 2008 to 2019
$17.1M
A Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseUM1HG009390 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2017 to 2021
$11.0M
(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2M
Yale Clinical Neuroscientist Training ProgramR25NS079193 · NINDS · YALE UNIVERSITY · PI HAFLER, DAVID A. · 2012 to 2023
$943k
NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA227473NHGRI NIH HHS UM1 HG009390NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI073748NIAID NIH HHS U19 AI089992NINDS NIH HHS R25 NS079193
6 · The paper itself

Abstract

Cellular metabolic remodeling is intrinsically linked to the development, activation, differentiation, function, and survival of T cells. T cells transition from a catabolic, naïve state to an anabolic effector state upon T cell activation. Subsequently, specialization of T cells into T helper (Th) subsets, including regulatory T cells (T

Indexed as

Multiple SclerosisT-Lymphocyte SubsetsFatty AcidsHumansLipidsLymphocyte ActivationFatty AcidsLipidsfatty acidsimmunometabolismmultiple sclerosisT cellT regulatory (Treg) cell

Identifiers

PMID35603182
PMCPMC9116144

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.