Diet, exercise & lifestyle × cardiovascular events

TrialCirculation2022

Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study.

Ronald B Goldberg et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 3,234 people · 2022

Range includes no effect

No clear effect on cardiovascular events

+3%−22% to +37%

Smaller than almost all for cardiovascular events

As reported

HR 1.03, 95% CI 0.78–1.37

One number in the abstract

the abstract, start to end

metformin versus placebo hazard ratio 1.03 (95% CI, 0.78-1.37;

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 1.030.78–1.37
MetforminDiet, exercise & lifestyleCardiovascular events

Diet, exercise & lifestyle × cardiovascular eventshelps?one trial

unlikelylikely
0.500.50 without it

Metformin × cardiovascular eventshelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
more certainless certain
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2 trials

Full record →Abstract, authors, funding and every citing paper · PMID 35603600