Observational studyInvestigative ophthalmology & visual science2022
Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia.
Observational study in Investigative ophthalmology & visual science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Structure function relationship of paracentral visual field impairment in myopic patients with primary open-angle glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Interaction of Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Pathophysiology and Clinical Implications.Journal of clinical medicine · 2026Review
- Differential Effects of Corneal Biomechanics on Superficial and Deep Vessel Density and Their Association with Central Visual Function in Glaucoma Patients with Myopia.Journal of clinical medicine · 2025Article
- Peripapillary intrachoroidal cavitation in myopic eyes with open-angle glaucoma: association with myopic fundus changes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Discriminating Diseases Mimicking Normal-Tension Glaucoma (NTG) from NTG.Journal of clinical medicine · 2024Article
- AI-based fully automatic analysis of retinal vascular morphology in pediatric high myopia.BMC ophthalmology · 2024Article
- Optic Nerve Head Curvature Flattening Is Associated with Central Visual Field Scotoma.Journal of clinical medicine · 2024Article
- Influence of Trabeculectomy with Mitomycin C on Longitudinal Changes in the Visual Field in Glaucoma Patients with High Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Editorial: Functional assessments of the ocular circulation.Frontiers in medicine · 2023Article
- Myopic tilted disc: Mechanism, clinical significance, and public health implication.Frontiers in medicine · 2023Review
- Factors Associated with Elevated Tumor Necrosis Factor-α in Aqueous Humor of Patients with Open-Angle Glaucoma.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to investigate the ocular and hemodynamic factors contributing to the central visual function in glaucoma patients with myopia. Methods: This study was a prospective observational study, which included 236 eyes of 140 patients with normal-tension glaucoma (NTG), which includes 114 eyes with mild myopia (axial length ≥24 and <26 mm) and 122 eyes with moderate-to-severe myopia (axial length ≥26 mm). Ocular characteristics were axial length and posterior pole profiles, including peripapillary atrophy (PPA) to disc area ratio, disc tilt ratio, disc torsion, and disc-foveal angle. Hemodynamic factors included standard deviation of the mean of qualified normal-to-normal intervals (SDNN) of a heart rate variability (HRV) test and vessel density (VD) parameters from optical coherence tomography angiography (OCTA). The root mean square error was estimated as a measure of the VD fluctuation. Association between ocular characteristics and VD parameters of the OCTA with the central sensitivity of the 10-degree visual field or the presence of central scotoma were analyzed. Results: Deep layer VD of the peripapillary and macular areas showed significant differences between mild and moderate-to-severe myopia (P = 0.034 and P = 0.045, respectively). Structural parameters, especially PPA to disc area ratio, had significant correlation with peripapillary VD parameters in myopic eyes. Lower SDNN value (ß = 0.924, P = 0.011), lower deep VD of the macular area (ß = 0.845, P = 0.001), and greater fluctuation of deep VD in the peripapillary area (ß = 1.517, P = 0.005) were associated with the presence of central scotoma in patients with glaucoma with myopia in multivariate logistic regression analysis. Conclusions: The structural changes by myopia, especially in the peripapillary region, affected VD parameters in myopic eyes. Lower deep VD and greater VD fluctuation in the peripapillary region showed association with central scotoma in patients with glaucoma with myopia, suggesting both structural and vascular changes by myopia may be related to central visual function in glaucoma patients with myopia.
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