Evidence map›Paper›PMID 35607994›Full record

Trial reportCirculation. Cardiovascular quality and outcomes2022

Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non-ST-Segment-Elevation Myocardial Infarction in China: 2006 to 2015.

Weihong Guo, Xue Du, Yan Gao, Shuang Hu, Yuan Lu, Rachel P Dreyer, Xi Li, Erica S Spatz, Frederick A Masoudi, Harlan M Krumholz and 1 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Cardiovascular quality and outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01624883 (The China PEACE), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01624883 completednot on this map

The China PEACE (Patient-centered Evaluative Assessment of Cardiac Events Retrospective Study of Acute Myocardial Infarction

TypeobservationalSponsorChina National Center for Cardiovascular DiseasesRan2012 to 2013Enrolled18,000ConditionsCoronary Heart Disease
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Gender disparities in coronary artery disease: a review of factors influencing clinical outcomes.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weihong GuoNational Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (W.G., X.D., Y.G., S.H., X.L., X.Z.).
Xue DuNational Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (W.G., X.D., Y.G., S.H., X.L., X.Z.).
Yan GaoNational Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (W.G., X.D., Y.G., S.H., X.L., X.Z.).
Shuang HuNational Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (W.G., X.D., Y.G., S.H., X.L., X.Z.).
Yuan LuCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (Y.L., R.P.D., E.S.S., H.M.K.).ORCID 0000-0001-5264-2169
Rachel P DreyerCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (Y.L., R.P.D., E.S.S., H.M.K.).ORCID 0000-0003-2861-1383
Xi LiNational Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (W.G., X.D., Y.G., S.H., X.L., X.Z.).ORCID 0000-0003-2249-688X
Erica S SpatzCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (Y.L., R.P.D., E.S.S., H.M.K.).ORCID 0000-0002-1557-7713
Frederick A MasoudiAscension Health, St Louis, MO (F.A.M.).
Harlan M KrumholzCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (Y.L., R.P.D., E.S.S., H.M.K.).ORCID 0000-0003-2046-127X
Xin ZhengNational Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China (W.G., X.D., Y.G., S.H., X.L., X.Z.).ORCID 0000-0002-6403-4790

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundSex differences in clinical characteristics and in-hospital outcomes among patients with non-ST-segment-elevation myocardial infarction have been described in Western countries, but whether these differences exist in China is unknown.

methodsWe used a 2-stage random sampling design to create a nationally representative sample of patients admitted to 151 Chinese hospitals for non-ST-segment-elevation myocardial infarction in 2006, 2011, and 2015 and examined sex differences in clinical profiles, treatments, and in-hospital outcomes over this time. Multivariable logistic regression models adjusting for age or other potentially confounding clinical covariates were used to estimate these sex-specific differences.

resultsAmong 4611 patients, the proportion of women (39.8%) was unchanged between 2006 and 2015. Women were older with higher rates of hypertension, diabetes, and dyslipidemia. Among patients without contraindications, women were less likely to receive treatments than men, with significant differences for aspirin in 2015 (90.3% versus 93.9%) and for invasive strategy in 2011 (28.7% versus 45.7%) and 2015 (34.0% versus 48.4%). After adjusting for age, such differences in aspirin and invasive strategy in 2015 were not significant, but the difference in invasive strategy in 2011 persisted. The sex gaps in the use of invasive strategy did not narrow. From 2006 to 2015, a significant decrease in in-hospital mortality was observed in men (from 16.9% to 8.7%), but not in women (from 11.8% to 12.0%), with significant interaction between sex and study year (

conclusionsSex differences in cardiovascular risk factors and invasive strategy after non-ST-segment-elevation myocardial infarction were observed between 2011 and 2015 in China. Although sex gaps in in-hospital mortality were largely explained by age differences, efforts to narrow sex-related disparities in quality of care should remain a focus. REGISTRATION: URL: http://www. CLINICALTRIALS: gov; Unique identifier: NCT01624883.

Indexed as

Non-ST Elevated Myocardial InfarctionSex CharacteristicsAspirinChinaFemaleHealthcare DisparitiesHumansMaleRetrospective StudiesTime FactorsTreatment OutcomeAspirinmortalitymyocardial infarctionquality of health carerisk factorssex characteristicswomen

Identifiers

PMID35607994
PMCPMC9208815

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.