Evidence map›Paper›PMID 35609807›Full record

ArticleCellular signalling2022

Decreased expression of ErbB2 on left ventricular epicardial cells in patients with diabetes mellitus.

Joanne T de Kay, Joshua Carver, Bailey Shevenell, Angela M Kosta, Sergey Tsibulnikov, Emily Certo, Douglas B Sawyer, Sergey Ryzhov, Michael P Robich

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02820233 (Isolation and Characterization of ERBB Expressing Human Heart Progenitor Cells), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02820233 recruitingnot on this map

Isolation and Characterization of ERBB Expressing Human Heart Progenitor Cells

TypeobservationalSponsorDouglas B. SawyerRan2015 to 2029Enrolled80ConditionsHeart Disease, Vascular Disease, Heart Failure
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Joanne T de KayMaine Medical Center Research Institute, Scarborough, ME, United States of America.
Joshua CarverMaine Medical Center Research Institute, Scarborough, ME, United States of America.
Bailey ShevenellMaine Medical Center Research Institute, Scarborough, ME, United States of America.
Angela M KostaMaine Medical Center Research Institute, Scarborough, ME, United States of America.
Sergey TsibulnikovMaine Medical Center Research Institute, Scarborough, ME, United States of America.
Emily CertoMaine Medical Center Research Institute, Scarborough, ME, United States of America.
Douglas B SawyerMaine Medical Center Research Institute, Scarborough, ME, United States of America; Maine Medical Center, Cardiovascular Institute, Portland, ME, United States of America.
Sergey RyzhovMaine Medical Center Research Institute, Scarborough, ME, United States of America. Electronic address: sryzhov@mmc.org.
Michael P RobichTufts Medical Center, Boston, MA, United States of America. Electronic address: michael.robich@outlook.com.
Maine Medical Center · USMaine Medical Center Research Institute · USTufts Medical Center · US

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN · 2017 to 2026
$51.6M
The role of night shift work in metabolic disorders during and after pregnancyP20GM121301 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN · 2017 to 2026
$25.1M
Telemedicine to Reduce Disparities in the Identification and Treatment of Neonatal EncephalopathyP20GM139745 · NIGMS · MAINEHEALTH · PI David B. Seder · 2021 to 2026
$19.2M
Optimizing Cardiovascular Stem Cells for Cardiac Repair and RegenerationU01HL100398 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HATZOPOULOS, ANTONIS · 2009 to 2015
$8.0M
Progenitor Cell Analysis CoreP30GM106391 · NIGMS · MAINEHEALTH · PI SATHYANARAYANA, PRADEEP · 2013 to 2017
$5.7M
Neuregulin signaling in myeloid cellsR01HL136560 · NHLBI · MAINEHEALTH · PI Sergey Ryzhov · 2017 to 2026
$3.3M
Molecular determinants of the fate of human heart mesenchymal progenitor cellsR01HL139887 · NHLBI · MAINEHEALTH · PI SAWYER, DOUGLAS B, VARY, CALVIN PARDEE HULL · 2019 to 2022
$2.0M
NHLBI NIH HHS R01 HL136560NHLBI NIH HHS R01 HL139887NHLBI NIH HHS U01 HL100398NIGMS NIH HHS P20 GM121301NIGMS NIH HHS P20 GM139745NIGMS NIH HHS P30 GM106391NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

We investigated the cell surface expression of ErbB receptors on left ventricular (LV) epicardial endothelial cells and CD105

Indexed as

Diabetes MellitusEndothelial CellsErb-b2 Receptor Tyrosine KinasesGlucoseHeart VentriclesHumansPhosphorylationSignal TransductionERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGlucoseADAM10Diabetes mellitusErbB receptorsHemoglobin A1CLV epicardial cells

Identifiers

PMID35609807
PMCPMC9671200
OpenAlexW4281263401

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.