Evidence map›Paper›PMID 35610277›Full record

ArticleScientific reports2022

Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.

Natsuko Kondo, Yoshinori Sakurai, Takushi Takata, Kuniyuki Kano, Kyo Kume, Munetoshi Maeda, Nobuhiko Takai, Shugo Suzuki, Fumihiro Eto, Kenji Kikushima and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Natsuko KondoParticle Radiation Oncology Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, 590-0494, Japan. kondo.natsuko.3x@kyoto-u.ac.jp.
Yoshinori SakuraiParticle Radiation Oncology Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, 590-0494, Japan.
Takushi TakataParticle Radiation Oncology Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, 590-0494, Japan.
Kuniyuki KanoDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Kyo KumeProton Medical Research Division, Research and Development Department, The Wakasa Wan Energy Research Center, Fukui, 914-0135, Japan.
Munetoshi MaedaProton Medical Research Division, Research and Development Department, The Wakasa Wan Energy Research Center, Fukui, 914-0135, Japan.
Nobuhiko TakaiDepartment of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, 859-3298, Japan.
Shugo SuzukiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, 545-8585, Japan.
Fumihiro EtoDepartment of Cellular and Molecular Anatomy and International Mass Imaging Center, Hamamatsu University School of Medicine, Shizuoka, 431-3192, Japan.
Kenji KikushimaDepartment of Cellular and Molecular Anatomy and International Mass Imaging Center, Hamamatsu University School of Medicine, Shizuoka, 431-3192, Japan.
Hideki WanibuchiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka, 545-8585, Japan.
Shin-Ichi MiyatakeCancer Center, Osaka Medical and Pharmaceutical University, Osaka, 569-8686, Japan.
Takayuki KajiharaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, 277-8562, Japan.
Shoji OdaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, 277-8562, Japan.
Mitsutoshi SetouDepartment of Cellular and Molecular Anatomy and International Mass Imaging Center, Hamamatsu University School of Medicine, Shizuoka, 431-3192, Japan.
Junken AokiDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Minoru SuzukiParticle Radiation Oncology Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, 590-0494, Japan.
Kyoto University · JPThe University of Tokyo · JPHamamatsu University School of Medicine · JPOsaka Metropolitan UniversityNagasaki International University · JPOsaka University of Pharmaceutical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain radiation necrosis (RN) or neurocognitive disorder is a severe adverse effect that may occur after radiation therapy for malignant brain tumors or head and neck cancers. RN accompanies inflammation which causes edema or micro-bleeding, and no fundamental treatment has been developed. In inflammation, lysophospholipids (LPLs) are produced by phospholipase A

Indexed as

LysophosphatidylcholinesMicrogliaAnimalsBrainChromatography, LiquidInflammationIvermectinLysophospholipidsMemory DisordersMiceNecrosisReceptors, Purinergic P2X4Tandem Mass SpectrometryIvermectinLysophosphatidylcholinesLysophospholipidsP2rx4 protein, mouseReceptors, Purinergic P2X4

Identifiers

PMID35610277
PMCPMC9130232
OpenAlexW4281388737

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.