Evidence map›Paper›PMID 35610365›Full record

ArticleBritish journal of cancer2022

Family history, obesity, urological factors and diabetic medications and their associations with risk of prostate cancer diagnosis in a large prospective study.

Visalini Nair-Shalliker, Albert Bang, Sam Egger, Xue Qin Yu, Karen Chiam, Julia Steinberg, Manish I Patel, Emily Banks, Dianne L O'Connell, Bruce K Armstrong and 1 more

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In one paragraph

Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Visalini Nair-ShallikerThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia. visalini.shalliker@sydney.edu.au.ORCID http://orcid.org/0000-0001-6277-5125
Albert BangThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.
Sam EggerThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.
Xue Qin YuThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.ORCID http://orcid.org/0000-0001-8638-7979
Karen ChiamThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.ORCID http://orcid.org/0000-0001-8154-6731
Julia SteinbergThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.
Manish I PatelSpecialty of Surgery, Sydney Medical School, The University of Sydney and Department of Urology, Westmead Hospital, Sydney, NSW, Australia.
Emily BanksNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.
Dianne L O'ConnellThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.
Bruce K ArmstrongSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
David P SmithThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales (NSW), Australia.ORCID http://orcid.org/0000-0002-1474-3214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer (PC) aetiology is unclear. PC risk was examined in relation to several factors in a large population-based prospective study.

methodsMale participants were from Sax Institute's 45 and Up Study (Australia) recruited between 2006 and 2009. Questionnaire and linked administrative health data from the Centre for Health Record Linkage and Services Australia were used to identify incident PC, healthcare utilisations, Prostate Specific Antigen (PSA) testing reimbursements and dispensing of metformin and benign prostatic hyperplasia (BPH) prescriptions. Multivariable Cox and Joint Cox regression analyses were used to examine associations by cancer spread, adjusting for various confounders.

resultsOf 107,706 eligible men, 4257 developed incident PC up to end 2013. Risk of PC diagnosis increased with: PC family history (versus no family history of cancer; HR

conclusionVasectomy and obesity are associated with an increased risk of advanced PC. The reduced risk of localised and advanced PC associated with BPH, and diabetes prescriptions warrants investigation.

Indexed as

Diabetes MellitusMetforminProstatic HyperplasiaProstatic NeoplasmsHumansMaleObesityProspective StudiesRisk FactorsMetformin

Identifiers

PMID35610365
PMCPMC9381576

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.