ArticleActa neuropathologica2022
Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis.
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Article in Acta neuropathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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33citing papers in PubMed, 1 pooled it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A new hope with CAR T-cell therapy for refractory idiopathic inflammatory myopathies: a systematic review.Journal of translational medicine · 2026Pooled it
- CAR-T therapy for immune-mediated necrotizing myopathy: a review of mechanisms and emerging clinical evidence.Clinical rheumatology · 2026Review
- An integrated reference atlas of human skeletal muscle.EBioMedicine · 2026Article
- Animal Models of Idiopathic Inflammatory Myopathies: Bridging Mechanistic Insights and Clinical Translation.International journal of molecular sciences · 2026Review
- Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis.Cell death & disease · 2026Article
- Disparate periphery and lung immune microenvironments induced monocyte-macrophage activation as a key factor in anti-synthetase syndrome-associated interstitial lung disease.Respiratory research · 2026Article
- Targeting microglial C1q alleviates blood-brain barrier disruption in the thalamus after cortical infarction.Journal of neuroinflammation · 2026Article
- The Evolving Landscape of CAR T-Cell Therapy in Autoimmune Diseases: A State-of-the-Art Review (2025).Clinical reviews in allergy & immunology · 2026Review
- Estrogen Stabilizes Interferon-Inducible Genes During Skeletal Muscle Regeneration.Biological research for nursing · 2026Article
- CAR-T and BiTE: new horizons in the treatment of rheumatic autoimmune diseases.Frontiers in immunology · 2026Review
- Challenges and strategies in clinical applications of CAR-T therapy for autoimmune diseases.Journal of hematology & oncology · 2025Review
- Characterization of Muscle Tissue Cell Diversity and Clinical Implications in Idiopathic Inflammatory Myopathy.Journal of cachexia, sarcopenia and muscle · 2025Article
- Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis.Scientific reports · 2025Article
- Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes.Aging and disease · 2025Review
- Local immunoglobulin expression in myositis is associated with interferon gamma signaling and correlates with disease activity.medRxiv : the preprint server for health sciences · 2025Article
- Targeting B Cells for the Treatment of Idiopathic Inflammatory Myopathy.Clinical reviews in allergy & immunology · 2025Review
- Idiopathic Inflammatory Myopathies: Recent Evidence Linking Pathogenesis and Clinical Features.International journal of molecular sciences · 2025Review
- Fever and rhabdomyolysis in a recent traveler: A case report of an uncommon presentation of anti-synthetase syndrome.SAGE open medical case reports · 2025Article
- Contribution of major histocompatibility complex class II immunostaining in distinguishing idiopathic inflammatory myopathy subgroups: A histopathological cohort study.Journal of neuropathology and experimental neurology · 2024Article
- [Peripheral neuroimmunological diseases - Neuropathological insights and clinical perspectives].Der Nervenarzt · 2024Article
Corrections and comments
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Authors and funding
33 authors at 12 institutions in 3 countries.
Corinna PreußeDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany.
Barbara PaeslerDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany.
Christopher NelkeDepartment of Neurology, Medical Faculty, Heinrich Heine University Hospital Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Derya CengizDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany.
Thomas MünteferingDepartment of Neurology, Medical Faculty, Heinrich Heine University Hospital Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Andreas RoosPediatric Neurology, Faculty of Medicine, University Children's Hospital, University of Duisburg-Essen, 45147, Essen, Germany.
Damien AmelinCentre of Research in Myology, Sorbonne Université, INSERM, Association Institut de Myologie, UMRS 974, 75013, Paris, France.
Yves AllenbachDepartment of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, 75013, Paris, France.
Akinori UruhaDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany.
Carsten DittmayerDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany.
Andreas HentschelLeibniz-Institut Für Analytische Wissenschaften - ISAS - E.V., 44139, Dortmund, Germany.
Marc PawlitzkiDepartment of Neurology with Institute for Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
Sarah HoffmannDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany.
Sara TimmCharité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Core Facility Electron Microscopy, 10117, Berlin, Germany.
Sarah Leonard LouisService de Neuromyologie, GH Pitié-Salpêtrière, University Hospital, 75013, Paris, France.
Nora F DenglerDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany.
Heinz WiendlDepartment of Neurology with Institute for Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
Jan D LünemannDepartment of Neurology with Institute for Translational Neurology, University Hospital Münster, 48149, Münster, Germany.
Albert SickmannLeibniz-Institut Für Analytische Wissenschaften - ISAS - E.V., 44139, Dortmund, Germany.
Baptiste HervierCentre of Research in Myology, Sorbonne Université, INSERM, Association Institut de Myologie, UMRS 974, 75013, Paris, France.
Sven G MeuthDepartment of Neurology, Medical Faculty, Heinrich Heine University Hospital Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Udo SchneiderDepartment of Rheumatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany.
Anne SchänzerInstitute of Neuropathology, Justus Liebig University Giessen, 35390, Giessen, Germany.
Sabine KrauseFriedrich-Baur-Institut, Labor Für Molekulare Myologie, Universität München, 81377, Munich, Germany.
Stylianos TomarasDepartment of Rheumatology, Helios Clinic Vogelsang, Gommern, Cooperation Partner of the Otto-Von-Guericke-University, 39245, Magdeburg, Germany.
Eugen FeistDepartment of Rheumatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, 10117, Berlin, Germany.
Rebecca HasseliDepartment of Rheumatology and Clinical Immunology, Justus-Liebig-University Giessen, Campus Kerckhoff, 61231, Bad Nauheim, Germany.
Hans-Hilmar GoebelDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany.
Laure GallayDepartment of Clinical Immunology, Edouard Herriot University Hospital, 69003, Lyon, France.
Nathalie StreichenbergerDepartment of Clinical Immunology, Edouard Herriot University Hospital, 69003, Lyon, France.
Olivier BenvenisteDepartment of Internal Medicine and Clinical Immunology, Pitié-Salpêtrière University Hospital, 75013, Paris, France.
Werner StenzelDepartment of Neuropathology, Institut Für Neuropathologie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Virchowweg 15 /Charitéplatz 1, 10117, Berlin, Germany. werner.stenzel@charite.de.
Tobias RuckDepartment of Neurology, Medical Faculty, Heinrich Heine University Hospital Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany. tobias.ruck@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0001-6332-8650
Humboldt-Universität zu Berlin · DEDüsseldorf University Hospital · DEInserm · FRHospices Civils de Lyon · FRJustus-Liebig-Universität Gießen · DELeibniz Institute for Analytical Sciences - ISAS · DEUniversity Hospital Münster · DEFriedrich Baur Stiftung · DEJohannes Gutenberg University Mainz · DEOtto-von-Guericke-Universität Magdeburg · DESorbonne Université · FRUniversity of Aberdeen · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anti-synthetase syndrome (ASyS)-associated myositis is a major subgroup of the idiopathic inflammatory myopathies (IIM) and is characterized by disease chronicity with musculoskeletal, dermatological and pulmonary manifestations. One of eight autoantibodies against the aminoacyl-transferase RNA synthetases (ARS) is detectable in the serum of affected patients. However, disease-specific therapeutic approaches have not yet been established.To obtain a deeper understanding of the underlying pathogenesis and to identify putative therapeutic targets, we comparatively investigated the most common forms of ASyS associated with anti-PL-7, anti-PL-12 and anti-Jo-1. Our cohort consisted of 80 ASyS patients as well as healthy controls (n = 40), diseased controls (n = 40) and non-diseased controls (n = 20). We detected a reduced extent of necrosis and regeneration in muscle biopsies from PL-12
Indexed as
LigasesMyositisAutoantibodiesHumansMuscle, SkeletalPlasma CellsProteomicsAutoantibodiesLigasesAnti-synthetase syndromeJo-1PathophysiologyPL-12PL-7Plasma cells
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.