Evidence map›Paper›PMID 35613619›Full record

ArticleNeuron2022

Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code.

Qijing Xie, Jiefu Li, Hongjie Li, Namrata D Udeshi, Tanya Svinkina, Daniel Orlin, Sayeh Kohani, Ricardo Guajardo, D R Mani, Chuanyun Xu and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. eLife · 2026
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  8. Review
  9. Journal of biological rhythms · 2025
    Article
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  12. bioRxiv : the preprint server for biology · 2025
    Article
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  16. Understanding the molecular diversity of synapses.Nature reviews. Neuroscience · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Cell-surface Milieu Remodeling in Human Dendritic Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Qijing XieDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Neurosciences Graduate Program, Stanford University, Stanford, CA 94305, USA.
Jiefu LiDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Hongjie LiDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Namrata D UdeshiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tanya SvinkinaThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniel OrlinVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Sayeh KohaniDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Ricardo GuajardoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
D R ManiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Chuanyun XuDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Tongchao LiDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Shuo HanDepartments of Genetics, Biology, and Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305, USA.
Wei WeiDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
S Andrew ShusterDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Neurosciences Graduate Program, Stanford University, Stanford, CA 94305, USA.
David J LuginbuhlDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Stephen R QuakeDepartments of Bioengineering and Applied Physics, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305, USA.
Swetha E MurthyVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Alice Y TingDepartments of Genetics, Biology, and Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305, USA.
Steven A CarrThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Liqun LuoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: lluo@stanford.edu.
Howard Hughes Medical Institute · USBroad Institute · USChan Zuckerberg Initiative (United States) · USOregon Health & Science University · US

Funding

Mapping protein communication between organs in homeostasis and diseaseR01DK121409 · NIDDK · HARVARD MEDICAL SCHOOL · PI CARR, STEVEN A, MCMAHON, ANDREW P. · 2018 to 2022
$8.3M
Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
Howard Hughes Medical InstituteNIDCD NIH HHS R01 DC005982NIDDK NIH HHS R01 DK121409
6 · The paper itself

Abstract

Transcription factors specify the fate and connectivity of developing neurons. We investigate how a lineage-specific transcription factor, Acj6, controls the precise dendrite targeting of Drosophila olfactory projection neurons (PNs) by regulating the expression of cell-surface proteins. Quantitative cell-surface proteomic profiling of wild-type and acj6 mutant PNs in intact developing brains, and a proteome-informed genetic screen identified PN surface proteins that execute Acj6-regulated wiring decisions. These include canonical cell adhesion molecules and proteins previously not associated with wiring, such as Piezo, whose mechanosensitive ion channel activity is dispensable for its function in PN dendrite targeting. Comprehensive genetic analyses revealed that Acj6 employs unique sets of cell-surface proteins in different PN types for dendrite targeting. Combined expression of Acj6 wiring executors rescued acj6 mutant phenotypes with higher efficacy and breadth than expression of individual executors. Thus, Acj6 controls wiring specificity of different neuron types by specifying distinct combinatorial expression of cell-surface executors.

Indexed as

Drosophila ProteinsOlfactory Receptor NeuronsAnimalsDendritesDrosophilaIon ChannelsMembrane ProteinsNerve Tissue ProteinsOlfactory PathwaysPOU Domain FactorsProteomicsTranscription Factorsacj6 protein, DrosophilaDrosophila ProteinsIon ChannelsMembrane ProteinsNerve Tissue ProteinsPiezo protein, DrosophilaPOU Domain FactorsTranscription Factorsantennal lobecell-surface proteincombinatorial codedendrite targetingDrosophilaolfactory circuitPiezoproteometranscription factorwiring specificity

Identifiers

PMID35613619
PMCPMC9308693
OpenAlexW4281400265

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.