Evidence map›Paper›PMID 35613697›Full record

SynthesisClinical immunology (Orlando, Fla.)2022

Serine and arginine rich splicing factor 1 deficiency alters pathways involved in IL-17A expression and is implicated in human psoriasis.

Shi Su, Xanthi-Lida Katopodi, Yered H Pita-Juarez, Emanual Maverakis, Ioannis S Vlachos, Iannis E Adamopoulos

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical immunology (Orlando, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Shi SuDepartment of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Xanthi-Lida KatopodiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Yered H Pita-JuarezDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Emanual MaverakisDepartment of Dermatology, University of California, Davis, Sacramento, CA, USA.
Ioannis S VlachosDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Harvard Medical School Initiative for RNA Medicine, Boston, MA, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Iannis E AdamopoulosDepartment of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: Iadamopo@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USHarvard University · USHarvard Affiliated Emergency Medicine Residency · USUniversity of California, Davis · US

Funding

The IL-23/IL-17 Axis in Inflammatory ArthritisR01AR062173 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEVY, DAN · 2012 to 2025
$4.9M
Role of splicing factor SRSF1 in T cell function and autoimmunityR01AR068974 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ADAMOPOULOS, IANNIS ELIAS · 2016 to 2020
$2.2M
NIAMS NIH HHS R01 AR062173NIAMS NIH HHS R01 AR068974
6 · The paper itself

Abstract

Serine and Arginine Rich Splicing Factor 1 (SRSF1) is a splicing factor that binds to exonic enhancers and stimulates splicing and is previously implicated with autoimmunity. Herein, we investigate the role of SRSF1 in regulating innate immune functions that are pertinent in the pathogenesis of auto-inflammatory diseases. Specifically, we show that conditional deletion of SRSF1 in mature lymphocytes resulted in higher expression of il-17a and il-17 f and an expansion of IL17A

Indexed as

Interleukin-17PsoriasisAlternative SplicingAnimalsArginineHumansMiceRNA Splicing FactorsSerineSerine-Arginine Splicing FactorsArginineInterleukin-17RNA Splicing FactorsSerineSerine-Arginine Splicing FactorsSRSF1 protein, humanAlternative splicingAutoimmunityIl-17PsoriasisSRSF1

Identifiers

PMID35613697
PMCPMC10797199
OpenAlexW4281286819

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.