Evidence map›Paper›PMID 35614852›Full record

ArticleBiophysical journal2022

Conserved Cdk inhibitors show unique structural responses to tyrosine phosphorylation.

Jacob B Swadling, Tobias Warnecke, Kyle L Morris, Alexis R Barr

Open access · hybridAbstract read
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. p57International journal of molecular sciences · 2024
    Article
  4. Article
  5. Slower CDK4 and faster CDK2 activation in the cell cycle.Structure (London, England : 1993) · 2024
    Article
  6. The fitness cost of spurious phosphorylation.bioRxiv : the preprint server for biology · 2023
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jacob B SwadlingInstitute of Clinical Sciences, Imperial College London, London, United Kingdom; MRC London Institute of Medical Sciences, London, United Kingdom. Electronic address: jacob.swadling@lms.mrc.ac.uk.
Tobias WarneckeInstitute of Clinical Sciences, Imperial College London, London, United Kingdom; MRC London Institute of Medical Sciences, London, United Kingdom.
Kyle L MorrisMRC London Institute of Medical Sciences, London, United Kingdom.
Alexis R BarrInstitute of Clinical Sciences, Imperial College London, London, United Kingdom; MRC London Institute of Medical Sciences, London, United Kingdom. Electronic address: a.barr@lms.mrc.ac.uk.
NIHR Imperial Biomedical Research Centre · GBMRC London Institute of Medical Sciences · GB

Funding

Cancer Research UK 25729Medical Research Council MC_UP_1102/7Medical Research Council MC_UP_1605/8
6 · The paper itself

Abstract

Balanced proliferation-quiescence decisions are vital during normal development and in tissue homeostasis, and their dysregulation underlies tumorigenesis. Entry into proliferative cycles is driven by Cyclin/Cyclin-dependent kinases (Cdks). Conserved Cdk inhibitors (CKIs) p21

Indexed as

Cell Cycle ProteinsCyclin-Dependent KinasesCyclin-Dependent Kinase 2CyclinsPhosphorylationProtein Processing, Post-TranslationalTyrosineCell Cycle ProteinsCyclin-Dependent Kinase 2Cyclin-Dependent KinasesCyclinsTyrosine

Identifiers

PMID35614852
PMCPMC9279356
OpenAlexW4281477995

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.