Evidence map›Paper›PMID 35617965›Full record

ArticleImmunity2022

Newly recruited intraepithelial Ly6A

Roham Parsa, Mariya London, Tiago Bruno Rezende de Castro, Bernardo Reis, Julian Buissant des Amorie, Jason G Smith, Daniel Mucida

Open access · greenAbstract read
In one paragraph

Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Local and circulating cytotoxic CD4medRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Roham ParsaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA. Electronic address: rparsa@rockefeller.edu.
Mariya LondonLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
Tiago Bruno Rezende de CastroLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY 10065, USA.
Bernardo ReisLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
Julian Buissant des AmorieLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
Jason G SmithDepartment of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA.
Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: mucida@rockefeller.edu.
Rockefeller University · USUniversity of Washington · US

Funding

INTESTINAL REGULATION OF ThPOK EXPRESSION AND CD4 HELPER T CELL FUNCTIONR01DK093674 · NIDDK · ROCKEFELLER UNIVERSITY · PI Daniel S Mucida · 2013 to 2026
$7.0M
Intestinal surveillance by intraepithelial lymphocytesR01DK113375 · NIDDK · ROCKEFELLER UNIVERSITY · PI Semir Beyaz, Daniel S Mucida · 2017 to 2026
$5.5M
Discovery of genetic elements regulating intraepithelial lymphocytesR21AI144827 · NIAID · ROCKEFELLER UNIVERSITY · PI MUCIDA, DANIEL S · 2019 to 2020
$466k
Howard Hughes Medical InstituteNIAID NIH HHS R21 AI144827NIDDK NIH HHS R01 DK093674NIDDK NIH HHS R01 DK113375
6 · The paper itself

Abstract

The intestinal epithelium comprises the body's largest surface exposed to viruses. Additionally, the gut epithelium hosts a large population of intraepithelial T lymphocytes, or IELs, although their role in resistance against viral infections remains elusive. By fate-mapping T cells recruited to the murine intestine, we observed an accumulation of newly recruited CD4

Indexed as

Intestine, SmallVirus DiseasesAnimalsAntigens, LyCD4-Positive T-LymphocytesIntestinal MucosaMembrane ProteinsMiceReceptors, ChemokineAntigens, LyLy6a protein, mouseMembrane ProteinsReceptors, Chemokinecytotoxic T cellsenteric virusintestinal epithelial cellsintraepithelial lymphocyteT cell differentiation

Identifiers

PMID35617965
PMCPMC9283333
OpenAlexW4281476739

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.