ArticleTissue engineering. Part A2022
Pharmaceutical Agents for Contractile-Metabolic Dysfunction After Volumetric Muscle Loss.
Article in Tissue engineering. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- 17β-Estradiol mitigates ovariectomy-induced defects in mitochondrial bioenergetics and redox balance after VML injury in female mice.American journal of physiology. Cell physiology · 2026Article
- Loss of ovarian hormones modulates sex-specific metabolic adaptations to volumetric muscle loss.American journal of physiology. Cell physiology · 2026Article
- Neurometabolic substrate utilization governs oxidative phosphorylation conductance in cortex and hippocampus.Journal of neurophysiology · 2026Article
- When rehabilitation is not enough, how targeting metabolism can overcome the limited plasticity of skeletal muscle after traumatic injury.Experimental physiology · 2026Review
- Retrospective transcriptomic analysis indicates temporal dysregulation of mitochondrial genes and metabolic pathways after volumetric muscle loss injury.Physiological reports · 2025Article
- Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.BMC musculoskeletal disorders · 2025Article
- Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice.American journal of physiology. Cell physiology · 2025Article
- Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of volumetric muscle loss.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Advancing β-adrenoreceptor agonism for recovery after volumetric muscle loss through regenerative rehabilitation and biomaterial delivery approaches.Regenerative biomaterials · 2025Article
- Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction.npj metabolic health and disease · 2024Article
- Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Differential effects of Western diet and traumatic muscle injury on skeletal muscle metabolic regulation in male and female mice.Journal of cachexia, sarcopenia and muscle · 2023Article
- Extracellular matrix: the critical contributor to skeletal muscle regeneration-a comprehensive review.Inflammation and regeneration · 2023Review
- Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury.Experimental physiology · 2023Article
- Exploring skeletal muscle tolerance and whole-body metabolic effects of FDA-approved drugs in a volumetric muscle loss model.Physiological reports · 2023Article
- Restricted physical activity after volumetric muscle loss alters whole-body and local muscle metabolism.The Journal of physiology · 2023Article
- The bioenergetic "CK Clamp" technique detects substrate-specific changes in mitochondrial respiration and membrane potential during early VML injury pathology.Frontiers in physiology · 2023Article
- Early initiation of electrical stimulation paired with range of motion after a volumetric muscle loss injury does not benefit muscle function.Experimental physiology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Volumetric muscle loss (VML) injuries represent a majority of military service member casualties and are common in civilian populations following blunt and/or penetrating traumas. Characterized as a skeletal muscle injury with permanent functional impairments, there is currently no standard for rehabilitation, leading to lifelong disability. Toward developing rehabilitative strategies, previous research demonstrates that the remaining muscle after a VML injury lacks similar levels of plasticity or adaptability as healthy, uninjured skeletal muscle. This may be due, in part, to impaired innervation and vascularization of the remaining muscle, as well as disrupted molecular signaling cascades commonly associated with muscle adaptation. The primary objective of this study was to assess the ability of four pharmacological agents with a strong record of modulating muscle contractile and metabolic function to improve functional deficits in a murine model of VML injury. Male C57BL/6 mice underwent a 15% multimuscle VML injury of the posterior hindlimb and were randomized into drug treatment groups (formoterol [FOR], 5-aminoimidazole-4-carboxamide riboside [AICAR], pioglitazone [PIO], or sildenafil [SIL]) or untreated VML group. At the end of 60 days, the injury model was first validated by comparison to age-matched injury-naive mice. Untreated VML mice had 22% less gastrocnemius muscle mass, 36% less peak-isometric torque, and 27% less maximal mitochondrial oxygen consumption rate compared to uninjured mice (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.