SynthesisJournal of the American Heart Association2022
Genetic Architecture of Plasma Alpha-Aminoadipic Acid Reveals a Relationship With High-Density Lipoprotein Cholesterol.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 15 citations in OpenAlex.
- The consumption of animal products is associated with plasma levels of alpha-aminoadipic acid (2-AAA).Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024Trial
- 2-Aminoadipic Acid mediates the association between BMI and Lipids: Evidence from the CLSA and BHS Cohorts and Mendelian randomization.American journal of preventive cardiology · 2026Article
- The Response of Alpha-Aminoadipic Acid (2-AAA) to Short Term Lysine Ingestion in Healthy Individuals.Endocrinology, diabetes & metabolism · 2026Article
- Association between dietary amino acid intake and the risk of metabolic dysfunction-associated steatotic liver disease.Journal of advanced research · 2026Article
- Urinary Ferritin: A Non-inflammatory Iron Marker Linked to Insulin Resistance and Metabolic Syndrome Components.Journal of obesity & metabolic syndrome · 2026Article
- Mendelian Randomization Study in East Asian Populations Supports the Causal Relationship Between Blood Metabolites and COPD: Insights from Amino Acids, Phospholipids, Vitamin D, and Trace Elements.International journal of chronic obstructive pulmonary disease · 2026Article
- Urinary metabolites associated with the long-term risk for chronic kidney disease incidence and progression in hypertensive patients.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities.Frontiers in pharmacology · 2025Review
- Integrated bioinformatic analysis of the shared molecular mechanisms between ANCA-associated vasculitis and atherosclerosis.Arthritis research & therapy · 2024Article
- Circulating amino acid signature features urea cycle alterations associated with coronary artery disease.Scientific reports · 2024Observational
- Metabolic Disturbances in a Mouse Model of MPTP/Probenecid-Induced Parkinson's Disease: Evaluation Using Liquid Chromatography-Mass Spectrometry.Neuropsychiatric disease and treatment · 2024Article
- L-Lysine supplementation affects dietary protein quality and growth and serum amino acid concentrations in rats.Scientific reports · 2023Article
- Association of alpha-aminoadipic acid (2-AAA) with cardiometabolic risk factors in healthy and high-risk individuals.medRxiv : the preprint server for health sciences · 2023Article
- Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges.Diabetologia · 2023Review
- Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals.Frontiers in endocrinology · 2023Article
- Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 1 country.
Mingjian ShiDepartment of Biomedical Informatics Vanderbilt University Medical Center Nashville TN.ORCID 0000-0003-1569-9822
Chuan WangDivision of Cardiovascular Medicine Department of Medicine Vanderbilt University Medical Center Nashville TN.
Hao MeiDepartment of Data Science School of Population Health University of Mississippi Medical Center Jackson MS.
Marinella TemprosaDepartment of Biostatistics and Bioinformatics Milken Institute School of Public HealthGeorge Washington University Rockville MD.ORCID 0000-0002-9976-745X
Jose C FlorezCenter for Genomic Medicine and Diabetes Unit Massachusetts General Hospital Boston MA.
Mark TripputiDepartment of Biostatistics and Bioinformatics Milken Institute School of Public HealthGeorge Washington University Rockville MD.
Jordi MerinoCenter for Genomic Medicine and Diabetes Unit Massachusetts General Hospital Boston MA.ORCID 0000-0001-8312-1438
Loren LipworthDivision of Epidemiology Department of Medicine Vanderbilt University Medical Center Nashville TN.
Xiao-Ou ShuDivision of Epidemiology Department of Medicine Vanderbilt University Medical Center Nashville TN.
Robert E GersztenDivision of Cardiovascular Medicine Beth Israel Deaconess Medical Center Boston MA.ORCID 0000-0002-6767-7687
Thomas J WangDepartment of Medicine UT Southwestern Medical Center Dallas TX.ORCID 0000-0003-4063-6508
Joshua A BeckmanDivision of Cardiovascular Medicine Department of Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0001-8332-8439
Jorge L GamboaDivision of Clinical Pharmacology Department of Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0002-4204-7670
Jonathan D MosleyDepartment of Biomedical Informatics Vanderbilt University Medical Center Nashville TN.ORCID 0000-0001-6421-2887
Jane F FergusonDivision of Cardiovascular Medicine Department of Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0001-6896-1025
Diabetes Prevention Program Research Group
Vanderbilt University Medical Center · USBroad Institute · USMilken Institute · USSouthwestern Medical Center · USUniversity of Mississippi Medical Center · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MPRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MPost-DDP Follow-up StudyU01DK048413 · NIDDK · UNIVERSITY OF WASHINGTON · PI KAHN, STEVEN EMANUEL · 1994 to 2021
$13.7MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH, RODEN, DAN M · 2015 to 2019
$13.0MPRIMARY PREVENTION TRIAL (DPT-2)U01DK048397 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1994 to 2021
$12.0MNIDDM PRIMARY PREVENTION TRIAL (DPT 2)U01DK048404 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1994 to 2021
$11.6MPRIMARY PREVENTION TRIAL (DPT-2)U01DK048339 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARANETA, MARIA ROSARIO GORREZ, MUDALIAR, SUNDER · 1994 to 2022
$11.4MNIDDM PRIMARY PREVENTION TRIALU01DK048412 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VENDITTI, ELIZABETH MARY · 1994 to 2021
$11.4MPRIMARY PREVENTION TRIALU01DK048387 · NIDDK · MEDSTAR RESEARCH INSTITUTE · PI MAGEE, MICHELLE FISCHMANN · 1994 to 2022
$11.1MNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCI NIH HHS UM1 CA173640NCRR NIH HHS M01 RR016587NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS R01 HL142856NHLBI NIH HHS U19 HL065962NICHD NIH HHS R01 HD074711NIDDK NIH HHS K23 DK100533NIDDK NIH HHS R01 DK108159NIDDK NIH HHS R01 DK117144NIDDK NIH HHS U01 DK048339NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048377NIDDK NIH HHS U01 DK048380NIDDK NIH HHS U01 DK048381NIDDK NIH HHS U01 DK048387NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048404NIDDK NIH HHS U01 DK048406NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048411NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048434NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048443NIDDK NIH HHS U01 DK048468NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD017985NIMHD NIH HHS HHSN268201800013ININDS NIH HHS R01 NS032830
Abstract
Background Elevated plasma levels of alpha-aminoadipic acid (2-AAA) have been associated with the development of type 2 diabetes and atherosclerosis. However, the nature of the association remains unknown. Methods and Results We identified genetic determinants of plasma 2-AAA through meta-analysis of genome-wide association study data in 5456 individuals of European, African, and Asian ancestry from the Framingham Heart Study, Diabetes Prevention Program, Jackson Heart Study, and Shanghai Women's and Men's Health Studies. No single nucleotide polymorphisms reached genome-wide significance across all samples. However, the top associations from the meta-analysis included single-nucleotide polymorphisms in the known 2-AAA pathway gene
Indexed as
AtherosclerosisDiabetes Mellitus, Type 22-Aminoadipic AcidChinaCholesterol, HDLCholesterol, LDLFemaleGenome-Wide Association StudyHumansKetoglutarate Dehydrogenase ComplexMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsTriglycerides2-Aminoadipic AcidCholesterol, HDLCholesterol, LDLDHTKD1 protein, humanKetoglutarate Dehydrogenase ComplexTriglycerides2‐aminoadipic acidgenome‐wide association studyHDL cholesterolMendelian randomization analysis
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.