Evidence map›Paper›PMID 35623315›Full record

Trial reportRedox biology2022

MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men.

S C Broome, T Pham, A J Braakhuis, R Narang, H W Wang, A J R Hickey, C J Mitchell, T L Merry

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Redox biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. MitoQ alleviates mitochondria damage in sepsis-acute lung injury in a citrate synthase dependent manner.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

S C BroomeDiscipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand. Electronic address: s.broome@auckland.ac.nz.
T PhamDiscipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Auckland Bioengineering Institute, Faculty of Science, The University of Auckland, Auckland, New Zealand.
A J BraakhuisDiscipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand.
R NarangSchool of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
H W WangSchool of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand; School of Biological Sciences, Faculty of Science, The University of Auckland, Auckland, New Zealand.
A J R HickeySchool of Biological Sciences, Faculty of Science, The University of Auckland, Auckland, New Zealand.
C J MitchellSchool of Kinesiology, University of British Columbia, Vancouver, Canada.
T L MerryDiscipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.
University of Auckland · NZUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of mitochondrial ROS in signalling muscle adaptations to exercise training has not been explored in detail. We investigated the effect of supplementation with the mitochondria-targeted antioxidant MitoQ on a) the skeletal muscle mitochondrial and antioxidant gene transcriptional response to acute high-intensity exercise and b) skeletal muscle mitochondrial content and function following exercise training. In a randomised, double-blind, placebo-controlled, parallel design study, 23 untrained men (age: 44 ± 7 years, VO

Indexed as

AntioxidantsExerciseAdultDietary SupplementsHumansMaleMiddle AgedMitochondriaMuscle, SkeletalOrganophosphorus CompoundsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, MessengerUbiquinoneAntioxidantsmitoquinoneOrganophosphorus CompoundsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, MessengerUbiquinoneAdaptationAntioxidantExerciseMitochondriaPerformanceROS

Identifiers

PMID35623315
PMCPMC9142706
OpenAlexW4281493670

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.