Evidence map›Paper›PMID 35624701›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease.

Charleine Zussy, Rijo John, Théo Urgin, Léa Otaegui, Claire Vigor, Niyazi Acar, Geoffrey Canet, Mathieu Vitalis, Françoise Morin, Emmanuel Planel and 6 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  5. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Charleine ZussyMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Rijo JohnDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Mumbai 400019, India.
Théo UrginMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Léa OtaeguiMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Claire VigorIBMM, Pôle Chimie Balard Recherche, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.ORCID 0000-0002-1569-0425
Niyazi AcarCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université de Bourgogne Franche-Comté, 21000 Dijon, France.
Geoffrey CanetMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Mathieu VitalisMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Françoise MorinDepartment of Psychiatry and Neurosciences, Faculty of Medicine, Laval University, CR-CHUQ, Québec City, QC G1V 0A6, Canada.
Emmanuel PlanelDepartment of Psychiatry and Neurosciences, Faculty of Medicine, Laval University, CR-CHUQ, Québec City, QC G1V 0A6, Canada.
Camille OgerIBMM, Pôle Chimie Balard Recherche, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.ORCID 0000-0002-5177-5792
Thierry DurandIBMM, Pôle Chimie Balard Recherche, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.
Shinde L RajshreeDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Mumbai 400019, India.
Laurent GivaloisMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Padma V DevarajanDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Mumbai 400019, India.
Catherine DesrumauxMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, France.
Inserm · FRÉcole Nationale Supérieure de Chimie de Montpellier · FRInstitute of Chemical Technology · INCentre hospitalier de l'Université Laval · CACentre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-11-LABX-0021Région Occitanie Neurospray prematuration programSATT AxLR prematuration program
6 · The paper itself

Abstract

Polyunsaturated fatty acids (PUFAs) are a class of fatty acids that are closely associated with the development and function of the brain. The most abundant PUFA is docosahexaenoic acid (DHA, 22:6

Indexed as

Alzheimer’s diseaseamyloid-β peptidecognitive impairmentcurcumindocosahexaenoic acidintranasalmicroemulsionomega-3 fatty acidsTau protein

Identifiers

PMID35624701
PMCPMC9137520
OpenAlexW4224868054

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.