ArticleAntioxidants (Basel, Switzerland)2022
Antioxidant and Wound Healing Potential of
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Cholecalciferol-load films for the treatment of nasal burns caused by cauterization of the hypertrophied inferior turbinate: formulation, in vivo study, and clinical assessment.Drug delivery and translational research · 2023Trial
- Experimental Investigation of the Effects of 'Nigella sativa' and 'Vitis vinifera' on Intraoral Wound Healing.Oral health & preventive dentistry · 2026Article
- Volatile composition of essential oils from major Egyptian Citrus cultivars: a multivariate chemometric approach.Scientific reports · 2026Article
- Ultrasound-assisted aqueous extract of Campanula macrostachya enhances fibroblast repair via antioxidant and cytokine-modulatory mechanisms.Protoplasma · 2026Article
- Chemical composition and insecticidal activity of essential oils from Citrus limon, Citrus aurantium, and Citrus margarita against Musca domestica.Scientific reports · 2026Article
- Phytochemical profiling ofRSC advances · 2026Article
- The Influence of Phyto-Active Incorporated Topical Formulations on Cell Migration in Scratch Assays andCurrent drug delivery · 2026Article
- Spirostan and spirosol saponin derivatives from Solanum muricatum Aiton and their cytotoxic activities: insights into bioactive compounds and molecular mechanisms.Scientific reports · 2025Article
- Sustainable MnOPharmaceuticals (Basel, Switzerland) · 2025Article
- Plant Extracts as Modulators of the Wound Healing Process-Preliminary Study.International journal of molecular sciences · 2025Article
- Development and Optimization of Grape Skin Extract-Loaded Gelatin-Alginate Hydrogels: Assessment of Antioxidant and Antimicrobial Properties.Pharmaceutics · 2025Article
- Antimicrobial potential of Citrus australasica F. Muell. against methicillin-resistant Staphylococcus aureus supported by in silico analysis.Scientific reports · 2025Article
- The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances.Frontiers in pharmacology · 2025Review
- Article
- An Advanced Combinatorial System fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis.RSC advances · 2024Article
- Antiplasmodial potential of phytochemicals from Citrus aurantifolia peels: a comprehensive in vitro and in silico study.BMC chemistry · 2024Article
- Antioxidant and Anticancer Activity ofLife (Basel, Switzerland) · 2024Article
- Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explored the in vivo wound healing potential of Vitis vinifera seed extract using an excision wound model with focus on wound healing molecular targets including TGFBR1, VEGF, TNF-α, and IL-1β. The wound healing results revealed that V. vinifera seed extract enhanced wound closure rates (p < 0.001), elevated TGF-β and VEGF levels, and significantly downregulated TNF-α and IL-1β levels in comparison to the Mebo®-treated group. The phenotypical results were supported by biochemical and histopathological findings. Phytochemical investigation yielded a total of 36 compounds including twenty-seven compounds (1−27) identified from seed oil using GC-MS analysis, along with nine isolated compounds. Among the isolated compounds, one new benzofuran dimer (28) along with eight known ones (29−36) were identified. The structure of new compound was elucidated utilizing 1D/2D NMR, with HRESIMS analyses. Moreover, molecular docking experiments were performed to elucidate the molecular targets (TNF-α, TGFBR1, and IL-1β) of the observed wound healing activity. Additionally, the in vitro antioxidant activity of V. vinifera seed extract along with two isolated compounds (ursolic acid 34, and β-sitosterol-3-O-glucopyranoside 36) were explored. Our study highlights the potential of V. vinifera seed extract in wound repair uncovering the most probable mechanisms of action using in silico analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.