Evidence map›Paper›PMID 35624778›Full record

ArticleAntioxidants (Basel, Switzerland)2022

The Inhibition of LPS-Induced Oxidative Stress and Inflammatory Responses Is Associated with the Protective Effect of (-)-Epigallocatechin-3-Gallate on Bovine Hepatocytes and Murine Liver.

Tianle Xu, Run Liu, Hao Zhu, Yu Zhou, Tianxu Pei, Zhangping Yang

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Protective Role of Rosmarinic Acid-EnrichedBiochemistry research international · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. EGCG Alleviates HFood science & nutrition · 2025
    Article
  18. FermentedNutrients · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tianle XuJoint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
Run LiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Hao ZhuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Yu ZhouCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Tianxu PeiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Zhangping YangJoint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-5479-8447
Yangzhou University · CN

Funding

National Natural Science Foundation of China 32102731;31872324
6 · The paper itself

Abstract

This study aimed to evaluate whether (-)-epigallocatechin-3-gallate (EGCG) alleviates hepatic responses to lipopolysaccharide (LPS)-induced inflammation and oxidation. Isolated bovine hepatocytes and BALB/c mice were used for LPS challenge and EGCG pretreatment experiments in vitro and in vivo. LPS-challenged (6 μg/mL) hepatocytes exhibited increased levels of NF-κB (p65 and IκBα) and MAPK (

Indexed as

antioxidant activitybovine hepatocytesEGCGhepatoprotectiveMAPK/NF-κB signaling

Identifiers

PMID35624778
PMCPMC9137641
OpenAlexW4229034749

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.