Evidence map›Paper›PMID 35625895›Full record

ArticleBiomedicines2022

The Effect of Nutritional Ketosis on Aquaporin Expression in Apolipoprotein E-Deficient Mice: Potential Implications for Energy Homeostasis.

Inês V da Silva, Sean Gullette, Cristina Florindo, Neil K Huang, Thomas Neuberger, A Catharine Ross, Graça Soveral, Rita Castro

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Inês V da SilvaResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.ORCID 0000-0002-2916-4848
Sean GulletteHuck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA 16802, USA.
Cristina FlorindoDepartment of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.ORCID 0000-0002-0664-5411
Neil K HuangDepartment of Nutritional Sciences, The Pennsylvania State University, State College, PA 16802, USA.ORCID 0000-0002-2849-7018
Thomas NeubergerHuck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA 16802, USA.ORCID 0000-0002-3965-9780
A Catharine RossDepartment of Nutritional Sciences, The Pennsylvania State University, State College, PA 16802, USA.ORCID 0000-0002-6180-9570
Graça SoveralResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.ORCID 0000-0001-8487-110X
Rita CastroDepartment of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.ORCID 0000-0002-4585-0741
Pennsylvania State University · USUniversity of Lisbon · PTTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketogenic diets (KDs) are very low-carbohydrate, very high-fat diets which promote nutritional ketosis and impact energetic metabolism. Aquaporins (AQPs) are transmembrane channels that facilitate water and glycerol transport across cell membranes and are critical players in energy homeostasis. Altered AQP expression or function impacts fat accumulation and related comorbidities, such as the metabolic syndrome. Here, we sought to determine whether nutritional ketosis impacts AQPs expression in the context of an atherogenic model. To do this, we fed

Indexed as

aquaporinsketogenic dietobesityvery low-carbohydrate diet

Identifiers

PMID35625895
PMCPMC9138310
OpenAlexW4280575783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.