Evidence map›Paper›PMID 35625910›Full record

ReviewBiomedicines2022

Thirty-Five-Year History of Desialylated Lipoproteins Discovered by Vladimir Tertov.

Victor Glanz, Evgeny E Bezsonov, Vladislav Soldatov, Alexander N Orekhov

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06590012 (Prospective Double-Blinded Randomized Placebo-controlled Multicenter Study Evaluating the Impact of Dietary Supplement "Tertinat" on Major Adverse Cardiovascular Events in ATherosclerotic Patients After Coronary Revascularization Surgery.), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06590012 phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation

Prospective Double-Blinded Randomized Placebo-controlled Multicenter Study Evaluating the Impact of Dietary Supplement "Tertinat" on Major Adverse Cardiovascular Events in ATherosclerotic Patients After Coronary Revascularization Surgery.

TypeinterventionalSponsorInstitute for Atherosclerosis Research, RussiaRan2024 to 2027Enrolled1,228ConditionsAtherosclerosis, Atheroscleroses, Coronary, Carotid AtherosclerosisArmsPlacebo, Tertinat
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Victor GlanzLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Evgeny E BezsonovLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0002-9382-8338
Vladislav SoldatovPharmacology and Clinical Pharmacology Department, Belgorod State National Research University, 308015 Belgorod, Russia.
Alexander N OrekhovLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0002-3318-4681
Belgorod National Research University · RUResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RURussian Scientific Center of Surgery · RUSechenov University · RU

Funding

Russian Science Foundation 20-15-00264
6 · The paper itself

Abstract

Atherosclerosis is one of the leading causes of death in developed and developing countries. The atherogenicity phenomenon cannot be separated from the role of modified low-density lipoproteins (LDL) in atherosclerosis development. Among the multiple modifications of LDL, desialylation deserves to be discussed separately, since its atherogenic effects and contribution to atherogenicity are often underestimated or, simply, forgotten. Vladimir Tertov is linked to the origin of the research related to desialylated lipoproteins, including the association of modified LDL with atherogenicity, autoimmune nature of atherosclerosis, and discovery of sialidase activity in blood plasma. The review will briefly discuss all the above-mentioned information, with a description of the current situation in the research.

Indexed as

atherogenicityatherosclerosisdesialylationlow-density lipoproteins (LDL)sialidasetrans-sialidase

Identifiers

PMID35625910
PMCPMC9138341
OpenAlexW4280646463

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.