Evidence map›Paper›PMID 35626730›Full record

ArticleCells2022

Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons.

Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fangyuan ZhouInstitute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany.ORCID 0000-0002-5620-6775
Katharina MetznerInstitute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany.
Patrick EngelInstitute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany.
Annika BalzulatInstitute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany.
Marco SisignanoInstitute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-7581-0951
Peter RuthDepartment of Pharmacology, Toxicology and Clinical Pharmacy, University of Tübingen, 72076 Tübingen, Germany.
Robert LukowskiDepartment of Pharmacology, Toxicology and Clinical Pharmacy, University of Tübingen, 72076 Tübingen, Germany.
Achim SchmidtkoInstitute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany.ORCID 0000-0001-7270-5075
Ruirui LuInstitute of Pharmacology and Clinical Pharmacy, Goethe University, 60438 Frankfurt am Main, Germany.
Goethe University Frankfurt · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transient receptor potential (TRP) ankyrin type 1 (TRPA1) channel is highly expressed in a subset of sensory neurons where it acts as an essential detector of painful stimuli. However, the mechanisms that control the activity of sensory neurons upon TRPA1 activation remain poorly understood. Here, using in situ hybridization and immunostaining, we found TRPA1 to be extensively co-localized with the potassium channel Slack (K

Indexed as

NociceptionTransient Receptor Potential ChannelsAnimalsMiceNerve Tissue ProteinsPainPotassium ChannelsPotassium Channels, Sodium-ActivatedSensory Receptor CellsTRPA1 Cation ChannelNerve Tissue ProteinsPotassium ChannelsPotassium Channels, Sodium-ActivatedSlo2 protein, mouseTransient Receptor Potential ChannelsTRPA1 Cation ChannelTrpa1 protein, mousedorsal root gangliamicepainslackTRPA1

Identifiers

PMID35626730
PMCPMC9140117
OpenAlexW4280503401

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.