Evidence map›Paper›PMID 35628549›Full record

ArticleInternational journal of molecular sciences2022

Short-Chain Fatty Acids Augment Differentiation and Function of Human Induced Regulatory T Cells.

Mingjing Hu, Bilal Alashkar Alhamwe, Brigitte Santner-Nanan, Sarah Miethe, Hani Harb, Harald Renz, Daniel P Potaczek, Ralph K Nanan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Gut microbiota modulation of systemic immunity and cancer immunotherapy: mechanisms, evidence, and therapeutic implications.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  7. Short-chain fatty acids.Nature metabolism · 2026
    Review
  8. Review
  9. Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B.Journal of clinical and translational hepatology · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
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  19. Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 4 countries.

Mingjing HuCharles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney, Sydney, NSW 2747, Australia.
Bilal Alashkar AlhamweInternational Inflammation (in-VIVO) Network, Worldwide Universities Network (WUN), West New York, NJ 10001, USA.ORCID 0000-0002-7120-0013
Brigitte Santner-NananCharles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney, Sydney, NSW 2747, Australia.
Sarah MietheInstitute of Laboratory Medicine, Philipps University of Marburg-Medical Faculty, Member of the German Center for Lung Research (DZL), and the Universities of Giessen and Marburg Lung Center (UGMLC), 35043 Marburg, Germany.
Hani HarbInternational Inflammation (in-VIVO) Network, Worldwide Universities Network (WUN), West New York, NJ 10001, USA.ORCID 0000-0001-8218-2538
Harald RenzInternational Inflammation (in-VIVO) Network, Worldwide Universities Network (WUN), West New York, NJ 10001, USA.ORCID 0000-0003-0602-7215
Daniel P PotaczekInternational Inflammation (in-VIVO) Network, Worldwide Universities Network (WUN), West New York, NJ 10001, USA.ORCID 0000-0003-0324-8506
Ralph K NananCharles Perkins Centre Nepean, Sydney Medical School Nepean, The University of Sydney, Sydney, NSW 2747, Australia.
Philipps University of Marburg · DEThe University of Sydney · AU

Funding

Australasian Women's and Children's Research Foundation OZWACDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) 416910386 - GRK 2573/1German Center for Lung Research (DZL) 82DZL00502/A2Nepean Medical Research Foundation NMRFUniversities Giessen and Marburg Lung Center UGMLCVon Behring-Röntgen-Foundation (Von Behring-Röntgen-Stiftung) 62-LV04
6 · The paper itself

Abstract

Regulatory T cells (Tregs) control immune system activity and inhibit inflammation. While, in mice, short-chain fatty acids (SCFAs) are known to be essential regulators of naturally occurring and in vitro induced Tregs (iTregs), data on their contribution to the development of human iTregs are sparse, with no reports of the successful SCFAs-augmented in vitro generation of fully functional human iTregs. Likewise, markers undoubtedly defining human iTregs are missing. Here, we aimed to generate fully functional human iTregs in vitro using protocols involving SCFAs and to characterize the underlying mechanism. Our target was to identify the potential phenotypic markers best characterizing human iTregs. Naïve non-Treg CD4

Indexed as

Fatty Acids, VolatilePropionatesT-Lymphocytes, RegulatoryButyratesCell DifferentiationHistonesHumansInfant, NewbornTransforming Growth Factor betaButyratesFatty Acids, VolatileHistonesPropionatesTransforming Growth Factor betabutyratehistone acetylationpropionateregulatory T cellsshort-chain fatty acids

Identifiers

PMID35628549
PMCPMC9143307
OpenAlexW4280627443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.