Evidence map›Paper›PMID 35629298›Full record

ArticleLife (Basel, Switzerland)2022

Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage.

Jing Wang, Sami Ullah Khan, Pan Cao, Xi Chen, Fengchong Wang, Di Zou, Honghui Li, Heng Zhao, Kaixiang Xu, Deling Jiao and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Jing WangKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Sami Ullah KhanKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Pan CaoKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Xi ChenKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Fengchong WangKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Di ZouKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Honghui LiKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Heng ZhaoKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Kaixiang XuKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.ORCID 0000-0001-6665-3360
Deling JiaoKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Chang YangKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Feiyan ZhuKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Yaxuan ZhangKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Yanhua SuKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Wenmin ChengKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Baoyu JiaKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Yubo QingKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Muhammad Ameen JamalKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.ORCID 0000-0001-9575-5999
Hong-Ye ZhaoKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Hong-Jiang WeiKey Laboratory for Porcine Gene Editing and Xenotransplantation in Yunnan Province, Kunming 650201, China.
Yunnan Agricultural University · CN

Funding

Major Science and Technology Project of Yunnan Province 202102AA310047National Key R&D Program of China 2019YFA0110700
6 · The paper itself

Abstract

As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function of PIK3C3 overexpression on the liver and other organs is still unknown. In this study, we successfully generated PIK3C3 transgenic pigs through somatic cell nuclear transfer (SCNT) by designing a specific vector for the overexpression of PIK3C3. Plasmid identification was performed through enzyme digestion and transfected into the fetal fibroblasts derived from

Indexed as

autophagyliver damagePIK3C3transgenic pigs

Identifiers

PMID35629298
PMCPMC9146193
OpenAlexW4224323757

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.