Evidence map›Paper›PMID 35629375›Full record

ReviewLife (Basel, Switzerland)2022

Treatment of Inherited Retinal Dystrophies with Somatic Cell Therapy Medicinal Product: A Review.

Giacomo Maria Bacci, Valentina Becherucci, Elisa Marziali, Andrea Sodi, Franco Bambi, Roberto Caputo

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. AAV-mediated transduction of songbird retina.Frontiers in physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Giacomo Maria BacciPediatric Ophthalmology Unit, Children's Hospital A. Meyer-University of Florence, 50139 Florence, Italy.ORCID 0000-0002-8741-4833
Valentina BecherucciCell Factory Meyer, Children's Hospital A. Meyer-University of Florence, 50139 Florence, Italy.ORCID 0000-0002-2711-0088
Elisa MarzialiPediatric Ophthalmology Unit, Children's Hospital A. Meyer-University of Florence, 50139 Florence, Italy.ORCID 0000-0002-6676-9379
Andrea SodiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.
Franco BambiCell Factory Meyer, Children's Hospital A. Meyer-University of Florence, 50139 Florence, Italy.ORCID 0000-0002-1945-8324
Roberto CaputoPediatric Ophthalmology Unit, Children's Hospital A. Meyer-University of Florence, 50139 Florence, Italy.
Meyer Children's Hospital · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inherited retinal dystrophies and retinal degenerations related to more common diseases (i.e., age-related macular dystrophy) are a major issue and one of the main causes of low vision in pediatric and elderly age groups. Advancement and understanding in molecular biology and the possibilities raised by gene-editing techniques opened a new era for clinicians and patients due to feasible possibilities of treating disabling diseases and the reduction in their complications burden. The scope of this review is to focus on the state-of-the-art in somatic cell therapy medicinal products as the basis of new insights and possibilities to use this approach to treat rare eye diseases.

Indexed as

advanced therapy medicinal productsembryonic stem cellsgood manufacturing practicesinduced pluripotent stem cellsinherited retinal dystrophiesmesenchymal stromal cellsretinal organoidsretinal progenitor cellsretinitis pigmentosasomatic cell therapy medicinal productsStargardt disease

Identifiers

PMID35629375
PMCPMC9147057
OpenAlexW4229450762

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.