Evidence map›Paper›PMID 35630558›Full record

ArticleMolecules (Basel, Switzerland)2022

Distinct Role of Mono-2-ethylhexyl Phthalate in Neuronal Transmission in Rat CA3 Hippocampal Neurons: Involvement of Ion Channels.

Yi Lu, Hong Wang, Junqing Yang, Wengao Jiang, Hong Xin, Ying Luo, Santiago Loya-López, Huaiyu Gu, Dongzhi Ran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi LuChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Hong WangChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Junqing YangChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Wengao JiangChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Hong XinDepartment of Pharmacy, People's Hospital of Xinjin District, Chengdu 611430, China.
Ying LuoChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Santiago Loya-LópezDepartment of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.
Huaiyu GuDepartment of Human Anatomy, Histology and Embryology, Peking Union Medical College, Beijing 100730, China.
Dongzhi RanChongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Chongqing Medical University · CNPeking Union Medical College Hospital · CNUniversity of Arizona · US

Funding

Chongqing Natural Science Foundation No. cstc2020jcyj-msxmX0706Youth Project of Science and Technology Research Program of Chongqing Education Commission of China No. KJQN202000412
6 · The paper itself

Abstract

Mono-(2-ethylhexyl) phthalate (MEHP) is one of the main active metabolites of di-(2-ethylhexyl) phthalate (DEHP). In our previous works, by using rat and Drosophila models, we showed a disruption of neural function due to DEHP. However, the exact neural effects of MEHP are still unclear. To explore the effects of MEHP on the central nervous system, the electrophysiological properties of spontaneous action potential (sAP), mini-excitatory postsynaptic currents (mEPSCs), ion channels, including Na

Indexed as

Diethylhexyl PhthalateAnimalsHippocampusIon ChannelsNeuronsPhthalic AcidsRatsSynaptic TransmissionDiethylhexyl PhthalateIon Channelsmono-(2-ethylhexyl)phthalatephthalic acidPhthalic Acidshippocampal neuronsion channelsMono-2-ethylhexyl phthalateneural excitabilityneuronal transmissionsynaptic plasticity

Identifiers

PMID35630558
PMCPMC9143894
OpenAlexW4280495776

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.