Evidence map›Paper›PMID 35630670›Full record

ReviewMolecules (Basel, Switzerland)2022

RETRACTED: Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases.

Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde, Md Mominur Rahman, Sakshi Painuli, Prabhakar Semwal, Polrat Wilairatana, Mohammad S Mubarak

RetractedOpen access · goldAbstract readReviewRetracted Publication
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 149 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 3 pooled it
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 3 syntheses or guidelines pooled it, 278 citations in OpenAlex.

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89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 7 countries.

Abdur RaufDepartment of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0003-2429-5491
Himani BadoniDepartment of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Premnagar, Dehradun 248006, India.ORCID 0000-0002-6915-7263
Tareq Abu-IzneidPharmaceutical Sciences Department, College of Pharmacy, Al Ain University for Science and Technology, Al Ain 64141, United Arab Emirates.ORCID 0000-0003-2252-6225
Ahmed OlatundeDepartment of Medical Biochemistry, Abubakar Tafawa Balewa University, Bauchi 740272, Nigeria.ORCID 0000-0002-8300-4538
Md Mominur RahmanDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.ORCID 0000-0003-2357-283X
Sakshi PainuliUttarakhand Council for Biotechnology (UCB), Premnagar, Dehradun 248007, India.ORCID 0000-0002-8941-2006
Prabhakar SemwalDepartment of Life Sciences, Graphic Era (Deemed To Be University), Dehradun 248002, India.ORCID 0000-0001-5137-5169
Polrat WilairatanaDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-2730-7788
Mohammad S MubarakDepartment of Chemistry, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0002-9782-0835
Abubakar Tafawa Balewa University · NGAl Ain University · AEDaffodil International University · BDGraphic Era University · INMahidol University · THUniversity of Jordan · JOUniversity of Swabi · PKUttarakhand State Council for Science and Technology · INUttaranchal University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes. Entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivation of these cells triggers the release of various neuroinflammatory markers (NMs), such as the tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-1β (IL-10), nitric oxide (NO), and cyclooxygenase-2 (COX-2), among others. Various studies have shown the role of neuroinflammatory markers in the occurrence, diagnosis, and treatment of neurodegenerative diseases. These markers also trigger the formation of various other factors responsible for causing several neuronal diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), ischemia, and several others. This comprehensive review aims to reveal the mechanism of neuroinflammatory markers (NMs), which could cause different neurodegenerative disorders. Important NMs may represent pathophysiologic processes leading to the generation of neurodegenerative diseases. In addition, various molecular alterations related to neurodegenerative diseases are discussed. Identifying these NMs may assist in the early diagnosis and detection of therapeutic targets for treating various neurodegenerative diseases.

Indexed as

Neurodegenerative DiseasesBiomarkersHumansInflammationInterleukin-1betaMicrogliaBiomarkersInterleukin-1betaastrocytescytokinesinflammationmicroglianeurodegenerative diseasesneuroinflammation

Identifiers

PMID35630670
PMCPMC9146652
OpenAlexW4280565855

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.