Evidence map›Paper›PMID 35630818›Full record

ArticleMolecules (Basel, Switzerland)2022

Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia.

Olumayokun A Olajide, Victoria U Iwuanyanwu, Owolabi W Banjo, Atsushi Kato, Yana B Penkova, George W J Fleet, Robert J Nash

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Iminosugars of the Invasive ArborealPlants (Basel, Switzerland) · 2025
    Article
  4. Effectiveness ofHealth science reports · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Olumayokun A OlajideDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
Victoria U IwuanyanwuDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.ORCID 0000-0002-2071-2035
Owolabi W BanjoDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
Atsushi KatoDepartment of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0001-8022-196X
Yana B PenkovaPhytoquest Limited, Plas Gogerddan, Aberystwyth SY23 3EB, UK.
George W J FleetChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.ORCID 0000-0003-1903-270X
Robert J NashPhytoquest Limited, Plas Gogerddan, Aberystwyth SY23 3EB, UK.ORCID 0000-0002-3272-640X
University of Huddersfield · GBAberystwyth University · GBToyama University Hospital · JPUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer's disease. (2) Methods. A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2

Indexed as

LipopolysaccharidesMicrogliaAmino AcidsAnimalsAnti-Inflammatory AgentsMiceNitric Oxide Synthase Type IIAmino AcidsAnti-Inflammatory AgentsLipopolysaccharidesNitric Oxide Synthase Type II(2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acidCucumis sativusiminosugar amino acid-idoBR1lipopolysaccharidemicroglia cell lineneuroprotectionpro-inflammatory factors

Identifiers

PMID35630818
PMCPMC9143674
OpenAlexW4281383165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.