Evidence map›Paper›PMID 35631065›Full record

ArticlePathogens (Basel, Switzerland)2022

Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of

Maya Gough, Dhiraj K Singh, Chivonne Moodley, Tianhua Niu, Nadia A Golden, Deepak Kaushal, Smriti Mehra

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Kynurenine Pathway in Respiratory Diseases.International journal of tryptophan research : IJTR · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maya GoughSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Dhiraj K SinghSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0001-5507-1197
Chivonne MoodleySouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Tianhua NiuDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
Nadia A GoldenTulane National Primate Research Center, Covington, LA 70433, USA.
Deepak KaushalSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0003-3521-1257
Smriti MehraSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0001-9923-8745
Texas Biomedical Research Institute · USTulane University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Viral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Deepak Kaushal, Kathryn Shelton · 2012 to 2026
$35.6M
ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
Immune Correlates of Protection from TBR01AI134240 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2017 to 2022
$4.8M
Perturbation of antigen-specific T cell responses in latent TB/SIV co-infectionR01AI111943 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2015 to 2019
$3.9M
Impact of concurrent HIV and latent TB therapies on Mtb-specific immune function-Diversity SupplementR01AI123047 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2017 to 2020
$3.9M
Genetic Requirements for the survival of Tubercle Bacilli in Nonhuman PrimatesR01AI089323 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2010 to 2014
$3.2M
Transcriptomics of Tuberculosis Latency and Reactivation in PrimatesR01HL106790 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2010 to 2013
$3.1M
Role of IDO in tryptophan pathway during Mycobacterial Tuberculosis infectionR21AI128130 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MEHRA, SMRITI · 2017 to 2018
$449k
Correlates of protection from TB and TB/AIDS comorbidityR21AI127222 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KOUSOULAS, KONSTANTIN G · 2016 to 2017
$425k
Characterization of Protective Immunity to MTB in a Setting of HIV CoinfectionR21AI127160 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KOUSOULAS, KONSTANTIN G · 2016 to 2017
$299k
Institutional award OD011133 and OD011104National Institute of Health SM (AI127160, AI127222 and AI128130) and DK (AI089323, HL106790, AI111914, AI111943, AI123047, AI134240)NHLBI NIH HHS R01 HL106790NIAID NIH HHS R01 AI089323NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI111943NIAID NIH HHS R01 AI123047NIAID NIH HHS R01 AI134240NIAID NIH HHS R21 AI127160NIAID NIH HHS R21 AI127222NIAID NIH HHS R21 AI128130NIH HHS P51 OD011104NIH HHS P51 OD011133NIH HHS U42 OD010442
6 · The paper itself

Abstract

Despite a century of research into tuberculosis (TB), there is a dearth of reproducible, easily quantifiable, biomarkers that can predict disease onset and differentiate between host disease states. Due to the challenges associated with human sampling, nonhuman primates (NHPs) are utilized for recapitulating the closest possible modelling of human TB. To establish a predictive peripheral biomarker profile based on a larger cohort of rhesus macaques (RM), we analyzed results pertaining to peripheral blood serum chemistry and cell counts from RMs that were experimentally exposed to

Indexed as

active tuberculosis diseaselatent tuberculosis infectionmacaque modelMycobacterium tuberculosis

Identifiers

PMID35631065
PMCPMC9146669
OpenAlexW4229012876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.