ArticleAging clinical and experimental research2022
The effect of ageing on fat infiltration of thigh and paraspinal muscles in men.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Exploring the associations between skeletal muscle echogenicity and physical function in aging adults: A systematic review with meta-analyses.Journal of sport and health science · 2024Pooled it
- Effects of high-intensity training on fatty infiltration in paraspinal muscles in elderly males with osteosarcopenia - the randomized controlled FrOST study.BMC geriatrics · 2024Trial
- Diagnostic Perspectives on the Relationship Between Paraspinal Muscles and Bone Mineral Density: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Association between TMG-derived contractile muscle parameters and MRI-based muscle structure in sarcopenia.BMC musculoskeletal disorders · 2026Article
- HMGB2-RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ultrasound and MRI Are Not Interchangeable for Measuring Muscle Cross-Sectional Area: Analysis of Reliability and Validity in 10 Lower Limb Muscles Considering Sex Differences.European journal of sport science · 2026Article
- Comprehensive quantitative analysis of muscle cross-sectional area and intramuscular fat infiltration of hip using modified DIXON MRI based on chemical shift encoding technique.Frontiers in aging · 2026Article
- Relationship between paraspinal sarcopenia and clinical outcomes of intervertebral disc degeneration patients following unilateral biportal endoscopy discectomy.BMC musculoskeletal disorders · 2025Article
- Intermuscular adipose tissue in healthy human aging-effects of exercise training and implications to metabolic health.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Developing a three-dimensional convolutional neural network for automated full-volume multi-tissue segmentation of the shoulder with comparisons to Goutallier classification and partial volume muscle quality analysis.Journal of shoulder and elbow surgery · 2025Article
- Improved Strength Prediction Combining MRI Biomarkers of Muscle Quantity and Quality.NMR in biomedicine · 2025Article
- Effects of Active Spinal Orthosis on Fatty Infiltration in Paraspinal Muscles in Kyphotic Women with Osteoporotic Vertebral Fracture-Sub-Analysis of a Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Intermuscular Adipose Tissue in CKD: A Window into Muscle Quality and Health?Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- A cross-sectional study on peroneal muscle echogenicity changes and their effects on balance functions in individuals with chronic ankle instability.Scientific reports · 2025Article
- Associations between abdominal fat, psoas muscle fat, and lumbar spine bone density: insights from quantitative CT imaging.BMC musculoskeletal disorders · 2025Article
- Muscle Disuse Atrophy.Advances in experimental medicine and biology · 2025Review
- The strength of associations between ultrasound measures of upper limb muscle morphology and isometric muscle strength: An exploratory study.Muscle & nerve · 2025Article
- Rectus Femoris Muscle Segmentation on Ultrasound Images of Older Adults Using Automatic Segment Anything Model, nnU-Net and U-Net-A Prospective Study of Hong Kong Community Cohort.Bioengineering (Basel, Switzerland) · 2024Article
- Muscle fat infiltration: a narrative review of the magnetic resonance (MR)-based evaluation methods and their clinical applications.Quantitative imaging in medicine and surgery · 2024Review
- Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals.GeroScience · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyosteatosis, skeletal muscle fat infiltration, is associated with inflammation and fibrosis. The age-related increase of myosteatosis is an important characteristic of sarcopenia and contributes to fragility.
aimsTo investigate the impact of healthy aging on intermuscular adipose tissue (IMAT) and muscle fat fraction (FF) in the thigh and the paraspinal muscles in males.
methodsIn 54 healthy males (age 20-70), all active hobby golfers, magnetic resonance imaging was performed to determine volume of IMAT, volume of muscle tissue (MT) and of percentage of FF.
resultsBetween ages 20-70, at the thigh, IMAT/MT volume and MT FF increased annually by 2.9% and 1.3%, respectively. At the psoas IMAT/Psoas volume did not change with age. MT FF increased by 1.5% annually. At the erector spinae IMAT/Erector volume decreased by 0.3% and MT FF increased by 2.8% annually. DISCUSSION: With increasing age, in males, thigh muscle atrophied, muscle tissue was partly replaced by adipose tissue and remaining muscle tissue also contained more fat. Similar effects were observed in the erector spinae. The psoas muscle did not atrophy, although MT FF also increased with age. Overall correlations with age were weak to moderate with higher correlations observed in the paraspinal muscles.
conclusionsAge-related increases of muscle fat infiltration were observed in the thigh and in the spine. Muscle atrophy did not occur in the psoas. In cross-sectional studies, an adjustment of volumetric parameters by muscle volume is advisable when comparing age-dependent results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.