Evidence mapPaperPMID 35634390Full record

ArticleFrontiers in nutrition2022

Assessing Insulin Sensitivity and Postprandial Triglyceridemic Response Phenotypes With a Mixed Macronutrient Tolerance Test.

John W Newman, Sridevi Krishnan, Kamil Borkowski, Sean H Adams, Charles B Stephensen, Nancy L Keim

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02298725 nacompletednot on this map

Individual Metabolism and Physiology Signature Study

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2014 to 2017Enrolled52ConditionsInsulin Resistance, Metabolic Syndrome X, ObesityArmsDGA Diet Plan, NHANES Diet Plan
NCT02367287 completednot on this map

Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study

TypeobservationalSponsorUSDA, Western Human Nutrition Research CenterRan2015 to 2019Enrolled393ConditionsObesity, Inflammation
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

John W NewmanWestern Human Nutrition Research Center, Agricultural Research Service, USDA, Davis, CA, United States.
Sridevi KrishnanDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Kamil BorkowskiWest Coast Metabolomics Center, Genome Center, University of California, Davis, Davis, CA, United States.
Sean H AdamsDepartment of Surgery, Davis School of Medicine, University of California, Davis, Sacramento, CA, United States.
Charles B StephensenWestern Human Nutrition Research Center, Agricultural Research Service, USDA, Davis, CA, United States.
Nancy L KeimWestern Human Nutrition Research Center, Agricultural Research Service, USDA, Davis, CA, United States.
University of California, Davis · USAgricultural Research Service · USWestern Human Nutrition Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of meal challenge tests to assess postprandial responses in carbohydrate and fat metabolism is well established in clinical nutrition research. However, challenge meal compositions and protocols remain a variable. Here, we validated a mixed macronutrient tolerance test (MMTT), containing 56-g palm oil, 59-g sucrose, and 26-g egg white protein for the parallel determination of insulin sensitivity and postprandial triglyceridemia in clinically healthy subjects. The MMTT was administered in two study populations. In one, women with overweight/obese BMIs ( Clinical Trial Registration: [https://clinicaltrials.gov/], identifier [NCT02298725; NCT02367287].

Indexed as

fat tolerance testinsulin patternsinsulin sensitivitymeal challenge testphenotypingpostprandial triglyceridemiatriglyceridemia

Identifiers

PMID35634390
PMCPMC9131925
OpenAlexW4280637705

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.