Evidence map›Paper›PMID 35635696›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Atomic Force Microscopy of DNA and DNA-Protein Interactions.

Philip J Haynes, Kavit H S Main, Bernice Akpinar, Alice L B Pyne

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  5. CoNanoscale · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Philip J HaynesLondon Centre for Nanotechnology, University College London, London, UK.
Kavit H S MainLondon Centre for Nanotechnology, University College London, London, UK.
Bernice AkpinarLondon Centre for Nanotechnology, University College London, London, UK.
Alice L B PyneLondon Centre for Nanotechnology, University College London, London, UK. a.l.pyne@sheffield.ac.uk.
London Centre for Nanotechnology · GBUniversity College London · GB

Funding

Cancer Research UKMedical Research Council MR/R024871/1Medical Research Council MR/R024871/2Wellcome Trust FC001119
6 · The paper itself

Abstract

Atomic force microscopy (AFM) is a microscopy technique that uses a sharp probe to trace a sample surface at nanometer resolution. For biological applications, one of its key advantages is its ability to visualize the substructure of single molecules and molecular complexes in an aqueous environment. Here, we describe the application of AFM to determine the secondary and tertiary structure of surface-bound DNA, and its interactions with proteins.

Indexed as

DNANanotechnologyMicroscopy, Atomic ForceProteinsDNAProteinsAFMAtomic force microscopyDNADNA-protein bindingDouble helixSupercoiling

Identifiers

PMID35635696
OpenAlexW4285214690

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.