Evidence map›Paper›PMID 35638415›Full record

Trial reportFrontiers in bioscience (Landmark edition)2022

Brief Post-Surgical Stress Management Reduces Pro-Inflammatory Cytokines in Overweight and Obese Breast Cancer Patients Undergoing Primary Treatment.

Molly Ream, Estefany Saez-Clarke, Chloe Taub, Alain Diaz, Daniela Frasca, Bonnie B Blomberg, Michael H Antoni

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in bioscience (Landmark edition), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02103387 (Five Sessions Intervention to Facilitate Adaptation to Breast Cancer), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02103387 nacompletednot on this map

Five Sessions Intervention to Facilitate Adaptation to Breast Cancer

TypeinterventionalSponsorUniversity of MiamiRan2007 to 2014Enrolled194ConditionsBreast CancerArmsCognitive Behavioral Training, Relaxation Training, Health Education Control
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Molly ReamDepartment of Psychology, University of Miami, Coral Gables, FL 33146, USA.
Estefany Saez-ClarkeDepartment of Psychology, University of Miami, Coral Gables, FL 33146, USA.
Chloe TaubDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Alain DiazDepartment of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33124, USA.
Daniela FrascaDepartment of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33124, USA.
Bonnie B BlombergDepartment of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33124, USA.
Michael H AntoniDepartment of Psychology, University of Miami, Coral Gables, FL 33146, USA.
University of Miami · USSylvester Comprehensive Cancer Center · USNorthwestern University · US

Funding

FACILITATING POSITIVE ADAPTATION TO BREAST CANCERR01CA064710 · UNIVERSITY OF MIAMI CORAL GABLES · 1994 to 2003
$1.9M
NCI NIH HHS R01 CA064710
6 · The paper itself

Abstract

backgroundOverweight and obese (OW/OB) body mass index (BMI) is associated with greater inflammation and poorer outcomes in breast cancer (BC). Stress management interventions using cognitive behavioral therapy (CBT) and relaxation training (RT) have reduced inflammation in BC patients but have not been tested specifically in OW/OB patients undergoing primary treatment. We developed brief CBT and RT-based group interventions and tested their effects (vs time-matched Health Education [HE] control) on serum inflammatory cytokines (IL-6, IL-1β and TNF-α) in OW/OB vs normal weight (NW) BC patients during primary treatment. We hypothesized OW/OB women would show higher levels of inflammatory cytokines, and that stress management would decrease these cytokines more in OW/OB women than in NW women.

methodsStage 0 - III BC patients were enrolled post-surgery and before initiating adjuvant therapy, were randomized to either 5 weeks of CBT, RT, or HE, and provided questionnaires and blood samples at baseline and 6-months. Serum cytokine levels were measured by ELISA. Repeated measures analysis of variance tested the interaction of condition by BMI by time in predicting cytokine levels over 6 months, controlling for age, stage, ethnicity, and income.

resultsThe sample (N = 153) majority was OW/OB (55.6%). We found differences in baseline IL-6 and IL-1β across BMI categories, with greater IL-6 (

conclusionsOW/OB women with newly diagnosed BC had significantly greater serum IL-6 and IL-1β than NW women post-surgery. Brief stress management delivered with primary treatment among OW/OB patients may reduce the increases in inflammatory markers known to accompany adjuvant treatments and could thus promote better outcomes. CLINICAL

trial registrationNCT02103387.

Indexed as

Breast NeoplasmsOverweightCytokinesFemaleHumansInflammationInterleukin-6ObesityTumor Necrosis Factor-alphaCytokinesInterleukin-6Tumor Necrosis Factor-alphabreast cancercognitive behavior therapyinflammationobeseoverweightrelaxationstress management

Identifiers

PMID35638415
PMCPMC9248770
OpenAlexW4229370270

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.