ReviewTrends in genetics : TIG2022
Gene product diversity: adaptive or not?
Review in Trends in genetics : TIG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Coding regions are rarely predefined in the eukaryotic genomes: a note on simplified models of gene architecture.BMC genomics · 2026Article
- Adaptive Spo11 RNA editing gate optimizes meiosis I pace and mitotic proliferation while preserving ascospore formation.Science advances · 2026Article
- Functionality versus Adaptation: Insights from Transcriptional Adaptation.Journal of molecular evolution · 2026Review
- Article
- Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis.Nature communications · 2026Article
- Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans.PLoS biology · 2026Article
- Why do we have so many different transcripts?PLoS biology · 2026Article
- Different mRNAs encoding identical proteins: how and why?Journal of applied genetics · 2026Article
- Can transcriptome size and off-target effects explain the contrasting evolution of mitochondrial vs nuclear RNA editing?Journal of evolutionary biology · 2025Article
- The implications of alternative splicing regulation for maximum lifespan.Nature communications · 2025Article
- The Implications of Alternative Splicing Regulation for Maximum Lifespan.bioRxiv : the preprint server for biology · 2025Article
- Promiscuous RNA editing in lncRNARNA (New York, N.Y.) · 2025Article
- An Ultimate Question for Functional A-to-I mRNA Editing: Why Not a Genomic G?Journal of molecular evolution · 2025Review
- Complete mitochondrial genome assembly and comparative analysis of Colocasia esculenta.BMC plant biology · 2025Article
- Most m5C Modifications in Mammalian mRNAs are Nonadaptive.Molecular biology and evolution · 2025Article
- Article
- Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects.BMC genomics · 2024Article
- Learning from the Codon Table: Convergent Recoding Provides Novel Understanding on the Evolution of A-to-I RNA Editing.Journal of molecular evolution · 2024Article
- mRNA Technology and Mucosal Immunization.Vaccines · 2024Review
- GTDrift: a resource for exploring the interplay between genetic drift, genomic and transcriptomic characteristics in eukaryotes.NAR genomics and bioinformatics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
One gene does not equal one RNA or protein. The genomic revolution has revealed numerous different RNA and protein molecules that can be produced from one gene, such as circular RNAs generated by back-splicing, proteins with residues mismatching the genomic encoding because of RNA editing, and proteins extended in the C terminus via stop codon readthrough in translation. Are these diverse products results of exquisite gene regulations or imprecise biological processes? While there are cases where the gene product diversity appears beneficial, genome-scale patterns suggest that much of this diversity arises from nonadaptive, molecular errors. This finding has important implications for studying the functions of diverse gene products and for understanding the fundamental properties and evolution of cellular life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.