Evidence map›Paper›PMID 35645683›Full record

ArticlePostepy dermatologii i alergologii2022

Nasra Ayuob, Etedal Hawuit, Zuhair M Mohammedsaleh, Dalia Shaalan, Maryam Mousa Hassn Hawasah, Khadija Abdulrhman Ahmed Basheikh, Soad Ali Shaker

Open access · goldAbstract read
In one paragraph

Article in Postepy dermatologii i alergologii, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Immunomodulatory Effects ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Nasra AyuobDepartment of Medical Histology, Faculty of Medicine, Damietta University, Damietta, Egypt.
Etedal HawuitDepartment of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Zuhair M MohammedsalehDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Saudi Arabia.
Dalia ShaalanDepartment of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Maryam Mousa Hassn HawasahPrince Abdul Majeed Health Consulting Center, Ministry of Health, Saudi Arabia.
Khadija Abdulrhman Ahmed BasheikhDiabetic and Endocrine Center in Jeddah, Ministry of Health, Saudi Arabia.
Soad Ali ShakerYousef Abdullatif Jameel, Chair of Prophetic Medical Applications (YAJCPMA), Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Damietta University · EGAssiut University · EGKing Abdulaziz University · SAMansoura University · EGMinistry of Health · SAUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The link between psychological stress and skin diseases, such as atopic dermatitis is established. Pumpkin was proved to have antioxidant, anti-inflammatory and accelerating wound healing potential. Aim: To assess the efficacy of pumpkin fruit ( Material and methods: Thirty male albino rats were exposed to chronic unpredictable mild stress (CUMS) for 4 weeks for induction of depression, then exposed to 1-fluoro-2,4-dinitrofluorobenzene (DNFB) for 2 weeks for induction of CD. The rats were then divided into 3 groups ( Results: The used PE included a large amount of oleic acid (about 56%) and a small amount of linoleic acid (about 1%). The topical application of PE significantly attenuated inflammation and oxidative changes attributed to CD associated with chronic stress-induced depression comparable to the standard treatment of CD. PE significantly alleviated signs and histopathological score of CD ( Conclusions: The pumpkin extract, applied topically in CD associated with depression, could be an alternative as well as preventive approach in treating CD. Anti-inflammatory and antioxidants activity of pumpkin is a proposed mechanism behind this effect. Further studies to test this effect on volunteer patients of CD are recommended.

Indexed as

CD4CD68contact dermatitisCox2 antioxidantsdepressioninflammatory cytokinespumpkin

Identifiers

PMID35645683
PMCPMC9131963
OpenAlexW3129675590

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.