Evidence map›Paper›PMID 35647197›Full record

ArticleJournal of diabetes research2022

FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes.

Tamara Vorobjova, Aili Tagoma, Ija Talja, Helis Janson, Anne Kirss, Raivo Uibo

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Metabolic Roles of Fatty Acid Binding Protein 4 (FABP4) in Fetal and Maternal Health and Maintenance of Pregnancy in Women with Obesity: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  2. Article
  3. Article
  4. Reproductive Immunology and Pregnancy 3.0.International journal of molecular sciences · 2023
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tamara VorobjovaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.ORCID https://orcid.org/0000-0002-2719-5747
Aili TagomaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
Ija TaljaDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
Helis JansonDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
Anne KirssWomen's Clinic, Tartu University Hospital, L. Puusepa 8, Tartu 51014, Estonia.
Raivo UiboDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
University of Tartu · EETartu University Hospital · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Gestational diabetes mellitus (GDM) is glucose intolerance detected initially during pregnancy. GDM poses an increased risk for the development of diabetes later in life. Fatty acid-binding protein 4 (FABP4) is a regulator of lipid metabolism and is associated with obesity, insulin resistance, and type 2 diabetes. Increased level of intestinal fatty acid-binding protein (I-FABP) may indicate impaired intestinal permeability, which may be an important contributor to the pathogenesis of type 1 diabetes and GDM. We aimed to compare FABP4 and I-FABP levels in pregnant women with GDM and in healthy pregnant controls, taking into consideration their prepregnancy body mass index (BMI), past exposures to enteroviruses (EV), and adipokine and cytokine levels, which have been shown to decrease insulin sensitivity. Results: FABP4 and I-FABP levels did not differ between women with GDM and healthy pregnant controls ( Conclusion: FABP4 and I-FABP levels were not dependent on the diagnosis of GDM, but rather on BMI. The correlation of I-FABP with adiponectin and resistin levels in women with GDM may suggests the importance of lipid metabolism in GDM-associated changes in intestinal permeability.

Indexed as

Body Mass IndexDiabetes, GestationalFatty Acid-Binding ProteinsInsulin ResistanceAdiponectinAdultFemaleHumansPregnancyPregnant PeopleResistinAdiponectinFABP2 protein, humanFABP4 protein, humanFatty Acid-Binding ProteinsResistin

Identifiers

PMID35647197
PMCPMC9142318
OpenAlexW4285742733

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.