Evidence map›Paper›PMID 35648365›Full record

ArticleObesity surgery2022

Changes of Short-Chain Fatty Acids and Their Receptors in an Obese Rat Model After Sleeve Gastrectomy.

Atsuro Fujinaga, Masayuki Ohta, Yuichi Endo, Hiroaki Nakanuma, Masahiro Kawamura, Yuka Hirashita, Takahide Kawasaki, Takashi Masuda, Teijiro Hirashita, Koro Gotoh and 1 more

Abstract read
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In one paragraph

Article in Obesity surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Atsuro FujinagaDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan. a-yoshimura@oita-u.ac.jp.ORCID 0000-0002-5856-9713
Masayuki OhtaDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Yuichi EndoDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Hiroaki NakanumaDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Masahiro KawamuraDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Yuka HirashitaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Takahide KawasakiDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Takashi MasudaDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Teijiro HirashitaDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Koro GotohDepartment of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.
Masafumi InomataDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Oita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShort-chain fatty acids (SCFAs) and gut microbiota have health-related effects and are associated with a wide range of disorders. However, the changes of SCFAs and their receptors after sleeve gastrectomy (SG) remain unclear. This study aimed to examine changes of SCFAs and their receptors after SG in an obese rat model.

methodsThirty obese Sprague-Dawley rats eating a high-energy diet for 6 weeks were divided into three groups: sham-operated (SO) control, pair-fed (PF) control, and SG group. Six weeks after the surgery, metabolic parameters, SCFA levels in the blood and stool, mRNA and protein expression of SCFA receptors in the ileum and epididymal fat, and gut microbiota were examined.

resultsMetabolic parameters in the SG group were significantly improved compared with the SO group. Acetic acid levels in the blood and stool were significantly higher in the SG group than the PF group. The butyric acid level in the stool was also significantly higher in the SG group than in the PF group. In the ileum and epididymal fat, mRNA and protein expression of GPR41 was significantly higher in the SG group than in the other two groups, and mRNA and protein expression of GPR43 was significantly higher in the SG group than in the PF group. Increases in the genera Enterococcus, Lactobacillus, Lactococcus, and Clostridium were observed in the stool after SG.

conclusionsSG may activate SCFA pathways through a change in gut microbiota.

Indexed as

Obesity, MorbidAnimalsFatty Acids, VolatileGastrectomyObesityRatsRats, Sprague-DawleyRNA, MessengerFatty Acids, VolatileRNA, MessengerBariatric surgeryGut microbiotaShort-chain fatty acid receptorsShort-chain fatty acidsSleeve gastrectomy

Identifiers

PMID35648365
OpenAlexW4281784290

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.