Evidence map›Paper›PMID 35651352›Full record

ArticleFrontiers in neurology2022

The Clinical Course of Early and Late Mild Cognitive Impairment.

Szu-Ying Lin, Po-Chen Lin, Yi-Cheng Lin, Yi-Jung Lee, Chen-Yu Wang, Shih-Wei Peng, Pei-Ning Wang

Abstract read
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In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Szu-Ying LinDepartment of Neurology, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
Po-Chen LinDoctoral Degree Program of Translational Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Hsinchu, Taiwan.
Yi-Cheng LinDepartment of Neurology, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
Yi-Jung LeeDivision of Neurology, Department of Medicine, Taipei City Hospital Renai Branch, Taipei, Taiwan.
Chen-Yu WangDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Shih-Wei PengDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Pei-Ning WangDivision of General Neurology, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Amnestic mild cognitive impairment (MCI) can be classified as either early MCI (EMCI) or late MCI (LMCI) according to the severity of memory impairment. The aim of this study was to compare the prognosis and clinical course between EMCI and LMCI. Methods: Between January 2009 and December 2017, a total of 418 patients with MCI and 146 subjects with normal cognition were recruited from a memory clinic. All the patients received at least two series of neuropsychological evaluations each year and were categorized as either EMCI or LMCI according to Alzheimer's Disease Neuroimaging Initiative 2 (ADNI2) criteria. Results: In total, our study included 161 patients with EMCI, 258 with LMCI, and 146 subjects with normal cognition as controls (NCs). The mean follow-up duration was 3.55 ± 2.18 years (range: 1-9). In a first-year follow-up assessment, 54 cases (32.8%) of EMCI and 16 (5%) of LMCI showed a normal cognitive status. There was no significant difference between the first year EMCI reverter and NCs in terms of dementia-free survival and further cognitive decline. However, first-year LMCI reverters still had a higher risk of cognitive decline during the following evaluations. Until the last follow-up, annual dementia conversion rates were 1.74, 4.33, and 18.6% in the NC, EMCI, and LMCI groups, respectively. The EMCI and LMCI groups showed a higher rate of progression to dementia (log-rank test, Conclusion: It is important to arrange follow-up visits for patients with MCI, even in the EMCI stage. One-year short-term follow-up may provide clues about the progression of cognitive function and help to identify relatively low-risk EMCI subjects.

Indexed as

Alzheimer's Diseasecognitive testsearly mild cognitive impairment (EMCI)longitudinal follow-upmild cognitive impairment (MCI)

Identifiers

PMID35651352
PMCPMC9149311

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.