Evidence map›Paper›PMID 35652188›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Magnesium-Encapsulated Injectable Hydrogel and 3D-Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration.

Zhi Yao, Weihao Yuan, Jiankun Xu, Wenxue Tong, Jie Mi, Pak-Cheong Ho, Dick Ho Kiu Chow, Ye Li, Hao Yao, Xu Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 128 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Zhi YaoMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Weihao YuanMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Jiankun XuMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Wenxue TongMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Jie MiMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Pak-Cheong HoDepartment of Orthopaedics & Traumatology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, SAR, 999077, China.
Dick Ho Kiu ChowMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Ye LiMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Hao YaoMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Xu LiMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Shunxiang XuMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Jiaxin GuoMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Qingtang ZhuDepartment of Microsurgery and Orthopedic Trauma, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, 510080, China.
Liming BianSchool of Biomedical Sciences and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, Guangdong Province, 510006, China.
Ling QinMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China.ORCID 0000-0001-6173-6167
Chinese University of Hong Kong · HKSouth China University of Technology · CNSun Yat-sen University · CN

Funding

Key-Area Research and Development Program of Guangdong Province 2019B010941001NSFC/RGC Joint Research Scheme N_CUHK405/21RGC Areas of Excellence AoE/M-402/20RGC Theme-based Research Scheme T13-402/17-N
6 · The paper itself

Abstract

Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting. Nevertheless, limited availability of autografts and potential morbidities in donors hampers its widespread application. Bioactive scaffold-based tissue engineering is a promising strategy to promote nerve regeneration. Additionally, magnesium (Mg) ions enhance nerve regeneration; however, an effectively controlled delivery vehicle is necessary to optimize their in vivo therapeutic effects. Herein, a bisphosphonate-based injectable hydrogel exhibiting sustained Mg

Indexed as

HydrogelsMagnesiumNerve RegenerationPeripheral Nerve InjuriesAnimalsAxonsPhosphatidylinositol 3-KinasesPolyestersRatsTissue EngineeringTissue ScaffoldsHydrogelsMagnesiumPhosphatidylinositol 3-KinasespolycaprolactonePolyestershydrogelmagnesiumperipheral nerve regeneration

Identifiers

PMID35652188
PMCPMC9313484
OpenAlexW4281699463

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.