Evidence map›Paper›PMID 35652247›Full record

ArticleEMBO reports2022

Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring.

Lamei Xue, Juan Sun, Jinxin Liu, Chaoping Hu, Dandan Wu, Chenzhipeng Nie, Kuiliang Zhang, Yu Wang, Lei Zhao, Xihua Li and 12 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 3 countries.

Lamei Xue *State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Juan Sun *State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Jinxin LiuState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.ORCID 0000-0003-0753-5342
Chaoping HuDepartment of Neuromuscular Disease, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0003-3938-6505
Dandan WuShanghai Key Laboratory of Stomatology, Department of Oral & Cranio-maxillofacial Science, Shanghai 9th People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chenzhipeng NieState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Kuiliang ZhangState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Yu WangState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Lei ZhaoDepartment of Neuromuscular Disease, Children's Hospital of Fudan University, Shanghai, China.
Xihua LiDepartment of Neuromuscular Disease, Children's Hospital of Fudan University, Shanghai, China.
Yan LuDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Li ZhangJoint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China.ORCID 0000-0003-1489-0879
Duo ZhangClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.ORCID 0000-0003-0361-4174
Mingcong FanState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Haifeng QianState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Haowen JiangState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-4419-7645
Jiemin WongShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.ORCID 0000-0002-5311-842X
Yuying LiChinese Academy of Sciences Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Hao YingChinese Academy of Sciences Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-8661-3670
Billy Kc ChowSchool of Biological Sciences, University of Hong Kong, Hong Kong, China.
Li WangState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.ORCID 0000-0002-6152-3484
Yan LiState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.ORCID 0000-0002-9402-1093
Jiangnan University · CNChildren's Hospital of Fudan University · CNChinese Academy of Sciences · CNEast China Normal University · CNJinan University · CNShanghai Institute of Materia Medica · CNShanghai Jiao Tong University · CNSun Yat-sen University · CNUniversity of Georgia · USUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our knowledge of the coordination of intergenerational inheritance and offspring metabolic reprogramming by gastrointestinal endocrine factors is largely unknown. Here, we showed that secretin (SCT), a brain-gut peptide, is downregulated by overnutrition in pregnant mice and women. More importantly, genetic loss of SCT in the maternal gut results in undesirable phenotypes developed in offspring including enhanced high-fat diet (HFD)-induced obesity and attenuated browning of inguinal white adipose tissue (iWAT). Mechanistically, loss of maternal SCT represses iWAT browning in offspring by a global change in genome methylation pattern through upregulation of DNMT1. SCT functions to facilitate ubiquitination and degradation of DNMT1 by activating AMPKα, which contributes to the observed alteration of DNMT1 in progeny. Lastly, we showed that SCT treatment during pregnancy can reduce the development of obesity and improve glucose tolerance and insulin resistance in offspring of HFD-fed females, suggesting that SCT may serve as a novel biomarker or a strategy for preventing metabolic diseases.

Indexed as

Insulin ResistanceSecretinAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsDiet, High-FatFemaleHumansMiceMice, Inbred C57BLObesityPregnancySecretinintergenerational effectsmetabolic homeostasisobesitysecretinwhite adipose tissue browning

Identifiers

PMID35652247
PMCPMC9253765
OpenAlexW4281614091

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.