Evidence map›Paper›PMID 35652341›Full record

SynthesisHypertension (Dallas, Tex. : 1979)2022

Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.

Tanika N Kelly, Xiao Sun, Karen Y He, Michael R Brown, Sarah A Gagliano Taliun, Jacklyn N Hellwege, Marguerite R Irvin, Xuenan Mi, Jennifer A Brody, Nora Franceschini and 96 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The genetics of hypertension.Nature reviews. Nephrology · 2026
    Review
  3. Article
  4. Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

106 authors.

Tanika N Kelly *Department of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0002-7348-4451
Xiao Sun *Department of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0001-8802-2957
Karen Y He *Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH (K.Y.H., X.Z.).ORCID 0000-0002-8686-7697
Michael R Brown *Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health (M.R.B., P.D.d.V., J.E.H., E.B., A.C.M.), The University of Texas Health Science Center at Houston' Houston' TX.ORCID 0000-0002-5235-9037
Sarah A Gagliano Taliun *Department of Biostatistics (S.A.G.T., S.D., H.M.K., J.L., G.R.A.), University of Michigan, Ann Arbor' MI.ORCID 0000-0003-1306-1868
Jacklyn N Hellwege *Division of Genetic Medicine, Department of Medicine (J.N.H.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-7479-0920
Marguerite R Irvin *Department of Epidemiology (M.R.I., S.A., N.D.A.), University of Alabama at Birmingham' AL.
Xuenan Mi *Department of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.
Jennifer A Brody *Cardiovascular Health Research Unit, Department of Medicine (J.A.B., K.E.N.), University of Washington, Seattle' WA.ORCID 0000-0001-8509-148X
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill (N.F.).ORCID 0000-0001-9755-2175
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance' CA (X.G., Y.-D.I.C., J.I.R., D.L.).ORCID 0000-0002-5264-5068
Shih-Jen HwangNational Heart, Lung and Blood Institute, Population Sciences Branch, National Institutes of Health, Framingham, MA (S.-J.H.).ORCID 0000-0002-2129-5704
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health (M.R.B., P.D.d.V., J.E.H., E.B., A.C.M.), The University of Texas Health Science Center at Houston' Houston' TX.ORCID 0000-0003-0964-0111
Yan GaoDepartment of Physiology and Biophysics (Y.G., E.E.K., R.J.F.L.), University of Mississippi Medical Center, Jackson' MS.
Arden MoscatiThe Charles Bronfman Institute for Personalized Medicine (A.M., G.N.N.), The Icahn School of Medicine at Mount Sinai, New York, NY.
Girish N NadkarniThe Charles Bronfman Institute for Personalized Medicine (A.M., G.N.N.), The Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-6319-4314
Lisa R YanekDivision of General Internal Medicine, Department of Medicine (L.R.Y., D.V.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0001-7117-1075
Tali ElfassyDivision of Epidemiology, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami' FL (T.E.).ORCID 0000-0002-7528-7988
Jennifer A SmithDepartment of Epidemiology (J.A.S., S.L.R.K.), University of Michigan, Ann Arbor' MI.ORCID 0000-0002-3575-5468
Ren-Hua ChungInstitute of Population Sciences, National Health Research Institutes, Taiwan (R.-H.C.).
Amber L BeitelsheesDivision of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore' MD (A.L.B., J.R.O., Y.-P.C.C., M.E.M., B.D.M.).ORCID 0000-0003-0958-7197
Amit PatkiDepartment of Biostatistics (A.P., V.S.), University of Alabama at Birmingham' AL.ORCID 0000-0003-2140-3856
Stella AslibekyanDepartment of Epidemiology (M.R.I., S.A., N.D.A.), University of Alabama at Birmingham' AL.
Brandon M BlobnerCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services (B.M.P.), University of Washington, Seattle' WA.ORCID 0000-0003-0734-1492
Juan M PeraltaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville' TX (J.M.P., J.E.C., J.B.).ORCID 0000-0002-8811-5579
Themistocles L AssimesDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford' CA (T.L.A.).ORCID 0000-0003-2349-0009
Walter R PalmasDivision of General Medicine, Department of Medicine, Columbia University, New York, NY (W.R.P.).
Chunyu LiuDepartment of Biostatistics, Boston University, Boston' MA (C.L.).
Adam P BressDivision of Health System Innovation and Research, Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City' UT (A.P.B.).ORCID 0000-0002-2259-5039
Zhijie HuangDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.
Lewis C BeckerDivision of Cardiology, Department of Medicine (L.C.B.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-4805-3403
Chii-Min HwaTaichung Veterans General Hospital, Taichung, Taiwan (C.-M.H.).ORCID 0000-0002-8209-9627
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore' MD (A.L.B., J.R.O., Y.-P.C.C., M.E.M., B.D.M.).
Jenna C CarlsonDepartment of Biostatistics, Graduate School of Public Health (J.C.C.), University of Pittsburgh, PA.
Helen R WarrenDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry (H.R.W., P.B.M.), Queen Mary University of London, United Kingdom.ORCID 0000-0003-0511-1386
Sayantan DasDepartment of Biostatistics (S.A.G.T., S.D., H.M.K., J.L., G.R.A.), University of Michigan, Ann Arbor' MI.
Ayush GiriBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville' TN (J.N.H., A.G., A.M.H., T.L.E.).
Lisa W MartinDivision of Cardiology, Department of Medicine, George Washington University, Washington, DC (L.W.M.).ORCID 0000-0003-4352-0914
W Craig JohnsonDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.ORCID 0000-0002-3161-3753
Ervin R FoxDivision of Cardiology, Department of Medicine (E.R.F.), University of Mississippi Medical Center, Jackson' MS.
Erwin P BottingerHasso Plattner Institute for Digital Health at Mount Sinai (E.P.B.), The Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-6868-6676
Alexander C RazaviDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0002-3213-0876
Dhananjay VaidyaDivision of General Internal Medicine, Department of Medicine (L.R.Y., D.V.), Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-7164-1601
Lee-Ming ChuangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei' Taiwan (L.-M.C.).ORCID 0000-0003-0978-2662
Yen-Pei C ChangDivision of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore' MD (A.L.B., J.R.O., Y.-P.C.C., M.E.M., B.D.M.).
Take NaseriMinistry of Health, Government of Samoa, Apia' Samoa (T.N.).
Deepti JainDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.
Hyun Min KangDepartment of Biostatistics (S.A.G.T., S.D., H.M.K., J.L., G.R.A.), University of Michigan, Ann Arbor' MI.
Adriana M HungDivision of Nephrology and Hypertension, Department of Medicine (A.M.H.), Vanderbilt University Medical Center, Nashville, TN.
Vinodh SrinivasasainagendraDepartment of Biostatistics (A.P., V.S.), University of Alabama at Birmingham' AL.
Beverly M SnivelyDivision of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC (B.M.S.).
Dongfeng GuDepartment of Epidemiology and Key Laboratory of Cardiovascular Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., J.H.).
May E MontasserDivision of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore' MD (A.L.B., J.R.O., Y.-P.C.C., M.E.M., B.D.M.).
Muagututi'a Sefuiva ReupenaLutia i Puava ae Mapu i Fagalele, Apia, Samoa (M.S.R.).
Benjamin D HeavnerDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.ORCID 0000-0003-2898-9044
Jonathon LeFaiveDepartment of Biostatistics (S.A.G.T., S.D., H.M.K., J.L., G.R.A.), University of Michigan, Ann Arbor' MI.ORCID 0000-0003-3668-6086
James E HixsonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health (M.R.B., P.D.d.V., J.E.H., E.B., A.C.M.), The University of Texas Health Science Center at Houston' Houston' TX.
Kenneth M RiceDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.
Fei Fei WangDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.
Jonas B NielsenDepartment of Internal Medicine: Cardiology (J.B.N.), University of Michigan, Ann Arbor' MI.ORCID 0000-0002-6654-2852
Jianfeng HuangTranslational Sciences Institute (T.N.K., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0002-1889-7907
Alyna T KhanDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.ORCID 0000-0002-2240-7931
Wei ZhouDepartment of Computational Medicine and Bioinformatics (W.Z.), University of Michigan, Ann Arbor' MI.
Jovia L NierenbergDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0003-2376-6714
Cathy C LaurieDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.
Nicole D ArmstrongDepartment of Epidemiology (M.R.I., S.A., N.D.A.), University of Alabama at Birmingham' AL.
Mengyao ShiDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0002-5883-0416
Yang PanDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0003-3487-7233
Adrienne M StilpDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.ORCID 0000-0002-3910-0776
Leslie EmeryDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.ORCID 0000-0002-9070-9886
Quenna WongDepartment of Biostatistics, School of Public Health (W.C.J., D.J., B.D.H., K.M.R., F.F.E., A.T.K., C.C.L., A.M.S., L.E., Q.W.), University of Washington, Seattle' WA.ORCID 0000-0002-9027-2100
Nicola L HawleyDepartment of Chronic Disease Epidemiology, Yale University, New Haven, CT (N.L.H.).
Ryan L MinsterDepartment of Human Genetics (B.M.B., R.L.M., D.E.W.), University of Pittsburgh, PA.ORCID 0000-0001-7382-6717
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville' TX (J.M.P., J.E.C., J.B.).ORCID 0000-0002-6898-155X
Patricia B MunroeDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry (H.R.W., P.B.M.), Queen Mary University of London, United Kingdom.ORCID 0000-0002-4176-2947
Daniel E WeeksDepartment of Human Genetics (B.M.B., R.L.M., D.E.W.), University of Pittsburgh, PA.
Kari E NorthCardiovascular Health Research Unit, Department of Medicine (J.A.B., K.E.N.), University of Washington, Seattle' WA.ORCID 0000-0002-8903-0366
Russell P TracyDepartment of Pathology & Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington' VT (R.P.T.).ORCID 0000-0002-0080-2420
Eimear E KennyDepartment of Physiology and Biophysics (Y.G., E.E.K., R.J.F.L.), University of Mississippi Medical Center, Jackson' MS.
Daichi ShimboDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (D.S.).
Aravinda ChakravartiDepartment of Medicine (A.C.), University of Mississippi Medical Center, Jackson' MS.
Stephen S RichCenter for Public Health, University of Virginia, Charlottesville' VA (S.S.R.).ORCID 0000-0003-3872-7793
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.P.R., C.K.).ORCID 0000-0002-1427-4470
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville' TX (J.M.P., J.E.C., J.B.).ORCID 0000-0001-6250-5723
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA (S.R.).ORCID 0000-0002-6585-1610
Braxton D MitchellDivision of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore' MD (A.L.B., J.R.O., Y.-P.C.C., M.E.M., B.D.M.).ORCID 0000-0003-4920-4744
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R.).
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance' CA (X.G., Y.-D.I.C., J.I.R., D.L.).ORCID 0000-0003-1741-3517
Sharon L R KardiaDepartment of Epidemiology (J.A.S., S.L.R.K.), University of Michigan, Ann Arbor' MI.
Robert C KaplanDivision of Social Medicine, Albert Einstein College of Medicine, Bronx, NY (R.C.K.).ORCID 0000-0003-1571-4615
Rasika A MathiasDivision of Allergy & Clinical Immunology, Department of Medicine (R.A.M.), Johns Hopkins University School of Medicine, Baltimore, MD.
Jiang HeDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0002-8286-9652
Bruce M PsatyDepartment of Epidemiology (T.N.K., X.S., X.M., Z.H., A.C.R., J.L.N., M.S., Y.P., J.H.), Tulane University, New Orleans, LA.ORCID 0000-0002-7278-2190
Myriam FornageBrown Foundation Institute of Molecular Medicine (M.F.), The University of Texas Health Science Center at Houston' Houston' TX.ORCID 0000-0003-0677-8158
Ruth J F LoosThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance' CA (X.G., Y.-D.I.C., J.I.R., D.L.).ORCID 0000-0002-8532-5087
Adolfo CorreaCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY (A.C.).ORCID 0000-0002-9501-600X
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health (M.R.B., P.D.d.V., J.E.H., E.B., A.C.M.), The University of Texas Health Science Center at Houston' Houston' TX.ORCID 0000-0001-8813-0544
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance' CA (X.G., Y.-D.I.C., J.I.R., D.L.).ORCID 0000-0001-7191-1723
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.P.R., C.K.).ORCID 0000-0002-7986-8560
Todd L Edwards *Division of Epidemiology, Department of Medicine (T.L.E.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-4318-6119
Gonçalo R Abecasis *Department of Biostatistics (S.A.G.T., S.D., H.M.K., J.L., G.R.A.), University of Michigan, Ann Arbor' MI.
Xiaofeng Zhu *Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH (K.Y.H., X.Z.).ORCID 0000-0003-0037-411X
Daniel Levy *The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance' CA (X.G., Y.-D.I.C., J.I.R., D.L.).ORCID 0000-0003-1843-8724
Donna K Arnett *College of Public Health, University of Kentucky, Lexington, KY (D.K.A.).ORCID 0000-0003-2219-657X
Alanna C Morrison *Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health (M.R.B., P.D.d.V., J.E.H., E.B., A.C.M.), The University of Texas Health Science Center at Houston' Houston' TX.ORCID 0000-0001-6381-4296
Samoan Obesity, Lifestyle, and Genetic Adaptations Study (OLaGA) Group,‡ NHLBI Trans-Omics for Precision Medicine TOPMed) Consortium

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Genomic Architecture of Common Disease in Diverse Populations: WGS of Ongoing Hemorrhagic Stroke Study SupplementUM1HG008898 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2016 to 2020
$77.0M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI VINING, EILEEN PATRICE · 1985 to 2007
$37.3M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
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6 · The paper itself

Abstract

backgroundThe availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.

methodsWe conducted a multiancestry whole-genome sequencing analysis of blood pressure among 51 456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program participants (stage-1). Stage-2 analyses leveraged array data from UK Biobank (N=383 145), Million Veteran Program (N=318 891), and Reasons for Geographic and Racial Differences in Stroke (N=10 643) participants, along with whole-exome sequencing data from UK Biobank (N=199 631) participants.

resultsTwo blood pressure signals achieved genome-wide significance in meta-analyses of stage-1 and stage-2 single variant findings ( DISCUSSION: We report one promising but unconfirmed rare variant for blood pressure and, more importantly, contribute insights for future blood pressure sequencing studies. Our findings suggest promise of aggregate analyses to complement single variant analysis strategies and the need for larger, diverse samples, and family studies to enable robust rare variant identification.

Indexed as

HypertensionBlood PressureGenome-Wide Association StudyGenomicsHumansPolymorphism, Single NucleotidePrecision Medicinealleleblood pressuregenomehypertensionwhole genome sequencing

Identifiers

PMID35652341
PMCPMC9593435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.